A Study to Assess Programmed Death Ligand-1 (PD-L1) Expression in Cytological Versus Histological Lung Cancer Specimens

  • Cancer
  • Lung Cancer
Please note that the recruitment status of the trial at your site may differ from the overall study status because some study sites may recruit earlier than others.
Trial Status:


This trial runs in
  • Czechia
  • Germany
  • Poland
  • Spain
  • Switzerland
  • United Kingdom
Trial Identifier:

NCT03092739 MO29978

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      The source of the below information is public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc.. It has been summarised and edited into simpler language. For more information about this clinical trial see the For Expert tab on the specific ForPatients page or follow these links to https://clinicaltrials.gov and/or https://euclinicaltrials.eu and/or https://www.isrctn.com.

      The below information is taken directly from public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc., and has not been edited.

      Results Disclaimer

      Trial Summary

      The primary purpose of this non-interventional, multinational study is to assess the feasibility of assessing PD-L1 protein expression on cytological samples as a surrogate for histological samples obtained from participants with any stage of non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC).

      Hoffmann-La Roche Sponsor
      N/A Phase
      NCT03092739,MO29978 Trial Identifier
      PD-L1 Immunocytochemistry (ICC), PD-L1 Immunohistochemistry (IHC) Treatments
      Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell Condition
      Official Title

      A Non-Interventional Multinational Study to Assess PD-L1 Expression in Cytological Versus Histological Non-Small Cell or Small Cell Lung Cancer Specimens

      Eligibility Criteria

      All Gender
      No Healthy Volunteers
      Inclusion Criteria
      • Samples must have been collected in a manner that is compliant with local ethics committee guidance
      • Samples must originate from participants diagnosed with NSCLC or SCLC
      • Participants must have a pair of at least one cytological and one histological specimen that: Both originate from inside the thorax or from the same ex-thoracic site; Are confirmed to have been collected within a window no more than 6 weeks apart from each other; and are in compliance with the protocol defined sample requirements for histological and cytological specimens
      Exclusion Criteria
      • Immune checkpoint inhibitor therapy from 4 weeks prior to collection of the first tumor sample until collection of the second matched sample

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