Safety and Tolerability of Atezolizumab (ATZ) in Combination With Radium-223 Dichloride (R-223-D) in Metastatic Castrate-Resistant Prostate Cancer (CRPC) Progressed Following Treatment With an Androgen Pathway Inhibitor

  • Cancer
  • Prostate Cancer
Please note that the recruitment status of the trial at your site may differ from the overall study status because some study sites may recruit earlier than others.
Trial Status:

Completed

This trial runs in
Country
  • United States
Trial Identifier:

NCT02814669 2015-003606-17 BO30013

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      The source of the below information is public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc.. It has been summarised and edited into simpler language. For more information about this clinical trial see the For Expert tab on the specific ForPatients page or follow these links to https://clinicaltrials.gov and/or https://euclinicaltrials.eu and/or https://www.isrctn.com.

      The below information is taken directly from public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc., and has not been edited.

      Results Disclaimer

      Trial Summary

      This study is designed to assess the safety and tolerability of atezolizumab when given in combination with radium-223 dichloride in participants with metastatic CRPC who have progressed after treatment with an androgen pathway inhibitor. This adaptive design study includes a cohort phase and a potential randomization phase. An initial concurrent dosing evaluation will evaluate the safety and tolerability of a treatment regimen that employs a concurrent start time for atezolizumab and radium-223 dichloride (Cohort 1). If concurrent dosing is found to be safe and tolerable in Cohort 1, additional participants will be enrolled and eligible participants will be randomized in a 1:1:1 ratio to Arms A, B, and C. If concurrent dosing is not tolerated in Cohort 1, new participants will be enrolled in a staggered dosing evaluation: Cohort 2 (28-day radium-223 dichloride run-in, atezolizumab will begin on Day 1 of Cycle 2) and Cohort 3 (56-day radium-223 dichloride run-in, atezolizumab will begin on Day 1 of Cycle 3). If the Cohort 2 schedule is tolerable, then additional participants will be enrolled using this treatment schedule; If the Cohort 2 schedule is not tolerable, subsequent participants will be enrolled in Cohort 3. If the Cohort 3 schedule is tolerable, then additional participants will be enrolled using this treatment schedule. If Cohort 3 schedule is not tolerable, no additional participant will be enrolled in the study.

      Hoffmann-La Roche Sponsor
      Phase 1 Phase
      NCT02814669,BO30013,2015-003606-17 Trial Identifier
      Atezolizumab, Radium-223 Dichloride Treatments
      Castrate-Resistant Prostate Cancer Condition
      Official Title

      A Phase Ib, Open-Label Study of the Safety and Tolerability of Atezolizumab in Combination With Radium-223 Dichloride in Patients With Castrate-Resistant Prostate Cancer Who Have Progressed Following Treatment With an Androgen Pathway Inhibitor

      Eligibility Criteria

      Male Gender
      ≥18 Years Age
      No Healthy Volunteers
      Inclusion Criteria
      • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
      • Life expectancy greater than or equal to (>/=) 12 weeks
      • Histologically confirmed, castrate-resistant adenocarcinoma of the prostate
      • Measurable disease according to RECIST v1.1
      • Multiple bone metastases within 12 weeks prior to study drug
      • Participants receiving bisphosphonate or denosumab therapy must have been on a stable dose for at least 4 weeks
      • Visceral metastasis and/or lymphadenopathy
      • Tumors that are amenable to serial biopsy
      • Disease progression according to Prostate Cancer Working Group 2 (PCWG2) criteria during or following treatment with at least one second generation androgen pathway inhibitor (for example, enzalutamide, abiraterone) for metastatic prostate cancer
      • Adequate hematologic and end-organ function
      • One prior taxane-containing regimen for mCRPC, or refusal or ineligibility of a taxane-containing regimen
      Exclusion Criteria
      • History of small-cell or neuroendocrine prostate carcinoma
      • Treatment with approved anti-cancer therapy (with the exception of abiraterone) within 3 weeks of study drug. Abiraterone must not be administered within 2 weeks prior to initiation of study treatment
      • Participation in another clinical trial/investigation within 28 days prior to study drug
      • Brain metastases or active leptomeningeal disease (with the exception of participants with treated epidural disease and no other epidural progression)
      • Uncontrolled tumor-related pain
      • Uncontrolled hypercalcemia
      • Significant cardiovascular disease
      • History of autoimmune disease except controlled/treated hypothyroidism, type 1 diabetes mellitus, or certain skin disorders
      • Prior allogeneic stem cell or solid organ transplant
      • History of pulmonary fibrosis/inflammation, including active tuberculosis
      • Human immunodeficiency virus (HIV) or hepatitis B or C
      • Prior treatment with cluster of differentiation (CD) 137 agonist, anti-programmed death (PD) 1, or anti-programmed death ligand (PD-L) 1 therapeutic antibody or pathway-targeting agents
      • Immunostimulants within 4 weeks or immunosuppressants within 14 days prior to study drug
      • Prior radium-223 dichloride or hemibody external radiotherapy
      • Systemic strontium-89, samarium-153, rhenium-186, or rhenium-188 for bone metastases within 24 weeks prior to initiation of study treatment
      • Spinal compression or structurally unstable bone lesions suggesting impending pathologic fractures based on clinical findings and/or magnetic resonance imaging (MRI)
      • Bone marrow dysplasia
      • Unmanageable fecal incontinence

      For the latest version of this information please go to www.forpatients.roche.com

       

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