A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment

A. Inclusion Criteria for Participants with DED:

• The participant reported dry eye-related ocular symptoms for at least 6 months before the screening visit
• The participant must have either used lubricant eye drops regularly OR had the desire to use lubricant eye drops in the past 3 months
• Participant must be classified as having moderate/severe DED
• The participant is deemed by the physician to require a prescription medication for DED (e.g., cyclosporin A or lifitegrast)

B. Inclusion Criteria for Healthy Volunteers:

• The participant does not have overt clinical signs of DED in either eye

• Intraocular pressure (IOP) >21.00 millimeters of mercury (mmHg) in either eye
• Acute allergic conjunctivitis in either eye within 3 months prior to screening
• Use of contact lenses within 30 days prior to screening
• Current punctal plugs or punctal cauterization or occlusion
• Use of ocular anti-inflammatory agents or ocular immunosuppressive agents within 3 months prior to screening
• Any intraocular injections (e.g., intravitreal [IVT] anti-vascular endothelial growth factor [VEGF]) within 3 months prior to screening, or such injections planned for within the study period
• Any intraocular immunosuppressive implants within 12 months prior to screening
• Any history of isotretinoin use within 12 months prior to screening
• Uncontrolled ocular or systemic disease