BN40697 - A study to look at tominersen safety over 15 months in people with Huntington’s disease

An Open-Label Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139)

  • Huntington's Disease
Trial Status:

Completed

This trial runs in
Countries
  • Canada
  • Germany
  • United Kingdom
  • United States
Trial Identifier:

NCT03342053 ISIS 443139-CS2 BN40697

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      The source of the below information is the publicly available website ClinicalTrials.gov. It has been summarised and edited into simpler language.

      The below information is taken directly from the publicly available website ClinicalTrials.gov within a week of any updates, and has not been edited.

      Results Disclaimer

      Trial Summary

      This study will test the safety, tolerability, pharmacokinetics and pharmacodynamics of RO7234292 administered intrathecally to adult patients with Huntington's Disease.

      Hoffmann-La Roche Sponsor
      Phase 2 Phase
      NCT03342053 , BN40697 , ISIS 443139-CS2 Trial Identifier
      RO7234292 (RG6042) Treatments
      Huntington's Disease Condition
      Official Title

      An Open-Label Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139)

      Eligibility Criteria

      All Gender
      ≥25 Years Age
      No Healthy Volunteers
      Inclusion Criteria

      Key Inclusion Criteria:

      • Must have completed dosing in ISIS 443139-CS1
      Exclusion Criteria

      Key Exclusion Criteria:

      • Any new condition or worsening of existing condition that could make the patient unsuitable for participation or interfere with the patient participating in and/or completing the study

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