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Cancer
Leukemia
A Study of Obinutuzumab Evaluating Efficacy, Safety and Cost of Disease Management in Participants With Chronic Lymphocytic Leukemia and Comorbidities
A study of the safety of a new medicine (DCLL9718S) in patients with a type of blood cancer (acute myeloid leukemia)
Observational Study to Monitor Safety and Effectiveness of Obinutuzumab in Follicular Lymphoma or Previously Untreated Chronic Lymphocytic Leukemia
A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
A Study of Venetoclax in Combination With Cobimetinib and Venetoclax in Combination With Idasanutlin in Patients Aged >/= 60 Years With Relapsed or Refractory Acute Myeloid Leukemia Who Are Not Eligible for Cytotoxic Therapy
An Observational Study of MabThera Subcutaneous (SC) Safety in Participants With Non-Hodgkin's Lymphoma (NHL) or Chronic Lymphocytic Leukemia (CLL)
A Study Evaluating the Safety and Pharmacology of Atezolizumab Administered in Combination With Immunomodulatory Agents in Participants With Acute Myeloid Leukemia (AML)
A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Comorbidities
Observational Study: Safety and Effectiveness of Obinutuzumab in Chronic Lymphocytic Leukemia in Argentina
A Study to Compare the Efficacy and Safety of Obinutuzumab + Venetoclax (GDC-0199) Versus Obinutuzumab + Chlorambucil in Participants With Chronic Lymphocytic Leukemia
A study to look at the safety and efficacy of obinutuzumab with bendamustine in people with a type of blood cancer called ‘chronic lymphocytic leukemia’ (GIBB)
A clinical trial to compare venetoclax plus obinutuzumab with fludarabine, cyclophosphamide and rituximab or bendamustine and rituximab in people with chronic lymphocytic leukemia.
Study to Evaluate the Safety and Pharmacokinetics of UTTR1147A in Combination With Standard of Care in Participants Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
A clinical trial to compare how safe and effective different doses of mosunetuzumab are in people with chronic lymphocytic leukaemia that has not responded to, or has come back after previous treatments
Ovarian Cancer
A clinical trial comparing atezolizumab with a placebo when given with chemotherapy (paclitaxel and carboplatin) and bevacizumab in people newly diagnosed with advanced ovarian, fallopian tube or peritoneal cancer.
An Observational Study of Avastin (Bevacizumab) in Patients With Advanced/Metastatic Epithelial Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer
A Study of the Efficacy and Safety of Bevacizumab in Chinese Women With Newly Diagnosed, Previously Untreated Stage III or Stage IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
A clinical trial to look at how well cobimetinib works in combination with another drug called niraparib to slow, stop or reverse the course of ovarian cancer, and whether it works better when it is given with or without another drug called atezolizumab.
A Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With Rucaparib in Participants With Advanced Breast, Ovarian Cancer, and Prostate Cancer.
Platinum-based Chemotherapy With Atezolizumab and Niraparib in Patients With Recurrent Ovarian Cancer (ENGOT-Ov41 / GEICO 69-O / ANITA)
Atezolizumab With Bevacizumab and Chemotherapy vs Bevacizumab and Chemotherapy in Early Relapse Ovarian Cancer
A clinical trial to look at the effects of different treatments on rare types of previously treated epithelial ovarian, fallopian tube or primary peritoneal cancers with different genetic changes
Colorectal Cancer
Study of Cobimetinib in Combination With Atezolizumab and Bevacizumab in Participants With Gastrointestinal and Other Tumors
A Real World Study to Evaluate Effectiveness of Avastin (Bevacizumab) for First Line Treatment of Patients With Metastatic Colorectal Cancer and Known KRAS Status
A Study to Assess the Impact of Sarcopenia on the Outcomes of Colorectal Cancer Patients Treated With Chemotherapy Combined With Bevacizumab
A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma (COTEZO IMblaze370)
A clinical trial to look at how well cibisatamab works in combination with another drug called atezolizumab after pre-treatment with obinutuzumab to treat advanced colorectal cancer (CRC) after chemotherapy has not worked
A Study of Biomarker-Driven Therapy in Metastatic Colorectal Cancer (mCRC)
A Study of BLYG8824A in Participants With Locally Advanced or Metastatic Colorectal Cancer
Study To Evaluate Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Anti-Tumor Activity Of RO7122290 In Combination With Cibisatamab With Obinutuzumab Pre-Treatment
A clinical trial to look at how well different targeted therapies work to treat metastatic colorectal cancer (mCRC)
Cervical Cancer
A Study to Evaluate Safety and Effectiveness of Bevacizumab in Combination With Paclitaxel and Cisplatin/Carboplatin or Toptecan in Participants With Advanced Cervical Cancer
Platinum Chemotherapy Plus Paclitaxel With Bevacizumab and Atezolizumab in Metastatic Carcinoma of the Cervix (ENGOT-Cx10 / GEICO 68-C / JGOG1084 / GOG-3030 / BEATcc)
A clinical trial to evaluate tiragolumab plus atezolizumab and atezolizumab on its own in people with cervical cancer (SKYSCRAPER-04)
Safety and Efficacy of Bevacizumab in Combination With Carboplatin and Paclitaxel for Metastatic, Recurrent or Persistent Cervical Cancer
Polycythemia Vera
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Idasanutlin Monotherapy in Participants With Hydroxyurea-Resistant/Intolerant Polycythemia Vera
A Study in Participants Previously Enrolled in a Genentech− and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
Bladder Cancer
A Study to Determine Best Tumor Response With Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2 (HER2) Overexpressing Solid Tumors
Safety and Pharmacology Study of Atezolizumab Alone and in Combination With Bacille Calmette-Guérin (BCG) in High-Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) Participants
A Study of the Safety of Atezolizumab in Patients With Advanced or Metastatic Urothelial Carcinoma in Argentina
A Study of Atezolizumab Versus Observation as Adjuvant Therapy in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (UC) After Surgical Resection
Study of Atezolizumab as Monotherapy and in Combination With Platinum-Based Chemotherapy in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma
A clinical trial to look at how well atezolizumab works when taken with other drugs, compared to atezolizumab alone, in people with bladder cancer
A clinical trial to compare the effectiveness and safety of atezolizumab with placebo in people with bladder cancer
A clinical trial to compare the effects of RO7247669 (also called ‘PD1-LAG3’) alone or in combination with tiragolumab versus atezolizumab in people with previously untreated urothelial cancer
Lung Cancer
A study to look at how well the drug called atezolizumab works (and how safe atezolizumab is) to treat different types of cancer in the real world, outside of controlled clinical trials
A Study of Atezolizumab Compared With Gemcitabine Plus (+) Cisplatin or Carboplatin for PD-L1-Selected Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower111)
A Study of Atezolizumab (Tecentriq®) in Ministry of Food and Drug Safety (MFDS)-Approved Indication(s)
A Study of Atezolizumab as Neoadjuvant and Adjuvant Therapy in Resectable Non-Small Cell Lung Cancer (NSCLC) - Lung Cancer Mutation Consortium (LCMC3)
A Study of Atezolizumab Compared With Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Containing Therapy
A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132)
A Study of MTIG7192A in Combination With Atezolizumab in Chemotherapy-Naïve Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
A clinical trial to understand the effect of targeted therapies for patients with non-­small cell lung cancer with different mutations (BFAST: Blood First Assay Screening Trial)
Neutropenic Sepsis in Patients With Non-Small Cell Lung Cancer Treated With Single-Agent Docetaxel and Associated Resource Use in the UK
Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]
Treatment Registry of Alectinib in Anaplastic Lymphoma Kinase (ALK)-Positive, Locally Advanced or Metastatic Non-Small Cell Lung Cancer in Korea
A Dose Finding and Expansion Study of RO7051790 Administered Orally in Participants With Relapsed, Extensive-Stage Disease Small Cell Lung Cancer (ED SCLC)
The Effectiveness Of Atezolizumab In Patients With Locally-Advanced Or Metastatic Non-Small Cell Lung Cancer After Prior Chemotherapy
A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)
A Clinical Trial to Compare Alectinib Versus Chemotherapy After Surgery in Patients with ALK-Positive Non-Small Cell Lung Cancer (ALINA)
A Study of the Efficacy and Safety of Alectinib in Participants With Anaplastic Lymphoma Kinase (ALK)-Rearranged Non-Small Cell Lung Cancer
A Study of Atezolizumab (Tecentriq) to Investigate Long-term Safety and Efficacy in Previously-treated Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)
A Study of the Safety of Atezolizumab in Participants With Locally Advanced or Metastatic Non Small Cell Lung Cancer in Argentina
Alectinib compared with chemotherapy in previously treated patients with ALK-positive NSCLC (ALUR)
A study of Atezolizumab for patients with non-small cell lung cancer (POPLAR)
A Clinical Trial to Compare Atezolizumab plus Chemotherapy versus Chemotherapy Alone Before Surgery in Patients with Non-Small Cell Lung Cancer (IMpower030)
A Study to Assess Programmed Death Ligand-1 (PD-L1) Expression in Cytological Versus Histological Lung Cancer Specimens
A Study of Atezolizumab (MPDL3280A) Compared With a Platinum Agent (Cisplatin or Carboplatin) + (Pemetrexed or Gemcitabine) in Participants With Stage IV Non-Squamous or Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower110]
A Study of Carboplatin Plus Etoposide With or Without Atezolizumab in Participants With Untreated Extensive-Stage (ES) Small Cell Lung Cancer (SCLC)
A Study of Atezolizumab as First-line Monotherapy for Advanced or Metastatic Non-Small Cell Lung Cancer
A clinical trial to compare atezolizumab given as an injection under the skin, with atezolizumab given as an infusion into the vein, in people with lung cancer who have previously received treatment with chemotherapy
A Study of Atezolizumab Compared With Docetaxel in Non-Small Cell Lung Cancer (NSCLC) After Failure With Platinum-Containing Chemotherapy
A Study to Investigate the Safety and Efficacy of Atezolizumab in Previously-Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Prospective Clinicogenomic Program
A Study of Bevacizumab, Carboplatin, and Paclitaxel or Pemetrexed With or Without Atezolizumab in Chemotherapy-Naïve Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer (IMpower151)
A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer
A clinical trial to compare tiragolumab plus atezolizumab with placebo plus atezolizumab in people with untreated advanced non-small cell lung cancer.
A Study of Alectinib, Entrectinib, or Vemurafenib Plus Cobimetinib in Participants With Stages I-III Non-Small Cell Lung Cancer With ALK, ROS1, NTRK, or BRAF v600E Molecular Alterations
A Study of Atezolizumab in Combination With Carboplatin Plus Etoposide to Investigate Safety and Efficacy in Patients With Untreated Extensive-Stage Small Cell Lung Cancer
Atezolizumab Consolidation in Limited Stage Small Cell Lung Cancer
A Study Comparing Alectinib With Crizotinib in Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer Participants
A Study of Atezolizumab in Combination With Bevacizumab in Patients With EGFR Mutation Positive Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
A clinical trial to compare atezolizumab and cabozantinib with docetaxel in people with metastatic non-small cell lung cancer (after previous treatment with a checkpoint inhibitor and platinum-containing chemotherapy has not worked).
A clinical trial to compare atezolizumab plus tiragolumab with durvalumab in people with Stage III non-small cell lung cancer that cannot be removed by surgery (unresectable) and whose cancer has not gotten worse after chemoradiotherapy (SKYSCRAPER-03)
A Study of Atezolizumab in Combination With Carboplatin + Paclitaxel or Carboplatin + Nab-Paclitaxel Compared With Carboplatin + Nab-Paclitaxel in Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower131]
A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases
A clinical trial to compare tiragolumab plus atezolizumab and chemotherapy with pembrolizumab and chemotherapy in people with untreated advanced non-small cell lung cancer
Study of Low-Dose Radiotherapy (LDRT) Concurrent Cisplatin/Carboplatin Plus Etoposide With Atezolizumab for Patients With Extensive-Stage Small Cell Lung Cancer
Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Participants With Untreated Extensive-Stage Small Cell Lung Cancer (SKYSCRAPER-02C)
A Study of Atezolizumab in Participants With Programmed Death - Ligand 1 (PD-L1) Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
A Study of Atezolizumab Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum-Containing Therapy
A Study of Atezolizumab in Combination With Carboplatin Plus (+) Paclitaxel With or Without Bevacizumab Compared With Carboplatin+Paclitaxel+Bevacizumab in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A Study of Atezolizumab in Combination With Carboplatin Plus (+) Nab-Paclitaxel Compared With Carboplatin+Nab-Paclitaxel in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A Study To Monitor Lung Cancer Patients Activity And Assess Performance Status Through A Wearable Device.
An Observational Study to Evaluate the Real-World Clinical Management and Outcomes of ALK-Positive Advanced NSCLC Participants Treated With Alectinib
A clinical trial to look at the safety and effectiveness of tiragolumab plus atezolizumab (with or without platinum-based chemotherapy) in patients with untreated locally advanced non-small cell lung cancer (NSCLC) that can be removed by surgery
A clinical trial to compare a medicine called pralsetinib with standard-of-care chemotherapy treatments in people with non-small cell lung cancer (NSCLC)
A Study of Atezolizumab Compared With Platinum Doublet Chemotherapy for PD-L1 Highly Expressed, Chemotherapy-Naïve Patients With Stage IV Non-Squamous or Squamous Non-Small Cell Lung Cancer
A clinical trial to compare atezolizumab plus lurbinectedin with atezolizumab alone after initial treatment with carboplatin, etoposide and atezolizumab in people with extensive-stage small-cell lung cancer (ES-SCLC)
A study to find out if taking different forms of a medicine (GDC-6036) results in the same amount of medicine in your body – and the effect of food on the medicine
A clinical trial to compare how effective and safe different targeted therapies (alectinib, entrectinib or pralsetinib) are compared with durvalumab in people with a type of lung cancer called non-small cell lung cancer (NSCLC) that has certain genetic mutations (ALK, ROS1 or RET)
A Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer
A clinical trial to look at how well atezolizumab works (and how safe the drug is) in people with inoperable locally advanced non-small cell lung cancer (NSCLC), whose cancer has not got worse after radiotherapy and platinum-based chemotherapy given together
A Phase II, single-arm study of tiragolumab plus atezolizumab and bevacizumab in patients with previously untreated locally advanced unresectable or metastatic PD-L1-positive non-squamous non-small cell lung cancer
A clinical trial to look at how safe and well RO7616789 works at different doses in people with small cell lung cancer (SCLC) that has spread or any neuroendocrine cancer, and how the body processes RO7616789
A clinical trial to compare RO7247669 plus platinum-based chemotherapy with pembrolizumab plus platinum-based chemotherapy in people with untreated non−small cell lung cancer that has grown or spread
Study of RO7515629 in Participants With HLA-G Positive Solid Tumors
A clinical trial to look at the safety and activity of GDC-6036 at different doses in combination with pembrolizumab or other anti-cancer therapies in people with untreated non-small cell lung cancer that has a KRAS G12C mutation and has spread
A Study to Evaluate the Impact of Liquid Biopsy in Participants With a Clinical Diagnosis of Advanced Cancer
Multiple Myeloma
A Study of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) Alone or in Combination With an Immunomodulatory Drug and/or Daratumumab in Participants With Multiple Myeloma (MM)
A Study of Cobimetinib Administered as Single Agent and in Combination With Venetoclax, With or Without Atezolizumab, in Participants With Relapsed and Refractory Multiple Myeloma
Dose-Escalation Study of BFCR4350A in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)
Study of Bromodomain and Extra-Terminal Protein (BET) Inhibitor RO6870810 as Mono- and Combination Therapy in Advanced Multiple Myeloma
A Study Evaluating The Safety And Pharmacokinetics Of Escalating Doses Of RO7297089 In Patients With Relapsed Or Refractory Multiple Myeloma
A Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of RO7425781 in Participants With Relapsed or Refractory Multiple Myeloma (r/r MM)
A clinical trial to look at the safety of cevostamab alone and in combination with other treatments in people with relapsed or refractory multiple myeloma
A Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Participants With Relapsed/Refractory Multiple Myeloma
A clinical trial to look at the effectiveness and safety of cevostamab in people with multiple myeloma after other treatments have not worked
A clinical trial to look at the safety and effectiveness of cevostamab in combination with lenalidomide in people with high-risk multiple myeloma receiving maintenance after transplant
A Dose-escalation Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma
Renal Cell Cancer
A Clinical Trial of Atezolizumab in Patients with Renal Cell Carcinoma that is at High Risk of Coming Back After Surgery (IMmotion010)
Study to Evaluate Safety, Pharmacokinetics and Therapeutic Activity of RO6874281 as a Combination Therapy in Participants With Unresectable Advanced and/or Metastatic Renal Cell Carcinoma (RCC)
A Study of Atezolizumab in Combination With Bevacizumab in Untreated Locally Advanced or Metastatic Clear Cell or Non-Clear Cell Renal Cell Carcinoma
A clinical trial to compare atezolizumab plus bevacizumab with active surveillance in people who have been treated for hepatocellular carcinoma (or HCC) through surgery or ablation, but who are at high risk of their HCC coming back.
A clinical trial to compare atezolizumab plus cabozantinib with cabozantinib alone in people with kidney cancer after checkpoint inhibitor treatment has not worked.
A Study of Atezolizumab in Combination With Bevacizumab Versus Sunitinib in Participants With Untreated Advanced Renal Cell Carcinoma (RCC)
A clinical trial to compare how well different combinations of drugs called immune checkpoint inhibitors work with axitinib in people with previously untreated kidney cancer (renal cell carcinoma) that has spread and cannot be removed with surgery
Melanoma
Cobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose Cancer Has Worsened During or After Treatment With Previous Immunotherapy and Atezolizumab Monotherapy in Participants With Previously Untreated Advanced Melanoma
A Study of Cobimetinib Plus Atezolizumab Versus Pembrolizumab in Participants With Previously Untreated Advanced BRAFv600 Wild-Type Melanoma
A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Patients With Metastatic or Unresectable Locally Advanced Melanoma
A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous System Metastases
A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State
A Study to Detect V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) V600 Mutation on Cell-Free Deoxyribonucleic Acid (cfDNA) From Plasma in Participants With Advanced Melanoma
A Study to Evaluate The Efficacy And Safety Of RO7198457 In Combination With Pembrolizumab Versus Pembrolizumab Alone In Participants With Previously Untreated Advanced Melanoma.
Atezolizumab in Combination With Bevacizumab in Patients With Unresectable Locally Advanced or Metastatic Mucosal Melanoma
A Study of Adult Participants With BRAF V600 Mutation-Positive Advanced Melanoma Treated With Cobimetinib (Cotellic®) During the French Early Access Program (Temporary Authorization for Use [TAU])
A clinical trial to look at how safe RO6874281 is in combination with another drug called pembrolizumab, and to look at how well the combination works to treat melanoma.
A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma
A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas
Hepatocellular Carcinoma
A Study of Hypoxia-inducible Factor 1a (HIF1A) Messenger Ribonucleic Acid (mRNA) Antagonist (RO7070179), to Demonstrate Proof-of-mechanism in Adult Participants With Hepatocellular Carcinoma (HCC)
A Clinical Trial to Compare Atezolizumab plus Bevacizumab with Sorafenib in Patients with Untreated Advanced Hepatocellular Carcinoma (IMbrave150)
A Phase I Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases
A Study of Atezolizumab (Tecentriq) in Combination With Bevacizumab to Investigate Safety and Efficacy in Patients With Unresectable Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy-Amethista
A Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocellular Carcionma
A Study of Atezolizumab in Combination With Bevacizumab in Spanish Patients With Unresectable or Unsuitable for Locoregional Treatments Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy
A clinical trial to compare atezolizumab plus lenvatinib or sorafenib with lenvatinib or sorafenib alone in people with advanced and/or inoperable HCC (after previous treatment with atezolizumab plus bevacizumab)
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)
A Study of Intravenous (IV) Cergutuzumab Amunaleukin and Atezolizumab in Combination in Participants With Locally Advanced and/or Metastatic Solid Tumors
Study to Explore the Mechanism of Acquired Immune Escape In Participants With Metastatic Cancer Progressing on CPI Therapy
Head and Neck Cancer
A clinical trial to compare atezolizumab with a placebo in people with head and neck cancer who are at a high risk of their cancer returning or getting worse after completion of standard initial therapy.
A clinical trial to evaluate atezolizumab plus tiragolumab and atezolizumab alone in people with squamous cell carcinoma of the head and neck
A Study of RO7121661 and RO7247669 Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus
A Phase I/Ib study evaluating single-agent inavolisib and inavolisib plus atezolizumab in PIK3CA-mutated cancers
A Study to Evaluate the Efficacy and Safety of Multiple Treatment Combinations in Patients with Locally Advanced Squamous Cell Carcinoma of Head and Neck
A Study of Emactuzumab and RO7009789 Administered in Combination in Participants With Advanced Solid Tumors
A Study to Determine the Excretion Balance, Pharmacokinetics, Metabolism and Absolute Oral Bioavailability of a Single Oral Dose of [14C]-Labeled Idasanutlin and an Intravenous Tracer Dose of [13C]-Labeled Idasanutlin in a Single Cohort of Participants With Solid Tumors (Malignancies)
Brain Tumor
Study of RXDX-101 in Children With Recurrent or Refractory Solid Tumors and Primary CNS Tumors, With or Without TRK, ROS1, or ALK Fusions
Pancreatic Cancer
A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)
Evaluate the Effect of Entrectinib on the Pharmacokinetics of Midazolam in Cancer Patients
My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors
A Study to Investigate the Bioequivalence or Relative Bioavailability of Three New Idasanutlin Tablet Variants Following Oral Administration in Participants With Solid Tumors
A Study to Investigate the Efficacy and Safety of Cobimetinib Plus Atezolizumab in Participants With Solid Tumors
A Study of the Safety and Efficacy of Atezolizumab Administered in Combination With Bevacizumab and/or Other Treatments in Participants With Solid Tumors
Study Evaluating the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Therapeutic Activity of Selicrelumab (RO7009789) With Vanucizumab or Bevacizumab in Participants With Metastatic Solid Tumors
A Clinical Trial to Compare Targeted Therapy or Cancer Immunotherapy with Chemotherapy in Patients with Cancer of Unknown Primary (CUPISCO)
An Extension (Rollover) Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Malignancies Previously Enrolled in an Antecedent Vemurafenib Protocol
A Phase I Study of BTRC4017A in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers
A Study of Atezolizumab in Advanced Solid Tumors
A Roll Over Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During Transfection (RET)-Positive Cancer
Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Participants With Previously Treated Solid Tumors
A Study of RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors
Safety and Pharmacokinetics (PK) of Escalating Doses of MTIG7192A as a Single Agent and in Combination With Atezolizumab in Locally Advanced or Metastatic Tumors
Prostate Cancer
A Study of Atezolizumab (Anti-PD-L1 Antibody) in Combination With Enzalutamide in Participants With Metastatic Castration-Resistant Prostrate Cancer (mCRPC) After Failure of an Androgen Synthesis Inhibitor And Failure of, Ineligibility For, or Refusal of a Taxane Regimen
Ipatasertib Plus Abiraterone Plus Prednisone/Prednisolone, Relative to Placebo Plus Abiraterone Plus Prednisone/Prednisolone in Adult Male Patients With Metastatic Castrate-Resistant Prostate Cancer
Safety and Tolerability of Atezolizumab (ATZ) in Combination With Radium-223 Dichloride (R-223-D) in Metastatic Castrate-Resistant Prostate Cancer (CRPC) Progressed Following Treatment With an Androgen Pathway Inhibitor
A clinical trial to compare the safety and effectiveness of ipatasertib plus atezolizumab and docetaxel in people with metastatic prostate cancer
A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer
A Study to Assess Pharmacokinetics and Safety of Atezolizumab Administered Intravenously (IV) as a Single Agent or in Combination With Chemotherapy to Chinese Participants With Locally Advanced or Metastatic Solid Tumors
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
Gastric Cancer
A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) (Morpheus-Gastric Cancer)
A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive Locally Advanced Resectable Gastric Cancer of Adenocarcinoma of Gastroesophageal Junction
A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastroesophageal Junction or Gastric Cancer
A Study to Explore the Efficacy and Safety of Atezolizumab Plus Tiragolumab and Chemotherapy in 1st Line HER2 Negative Unresectable, Recurrent or Metastatic Gastric Cancer or Adenocarcinoma of Gastroesophageal Junction (GEJ)
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-Care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
A Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract
An Extension Study to Provide Continued Bevacizumab Therapy to Participants With Solid Tumors Who Were Previously Enrolled in a Roche/Genentech Sponsored Study
CUP
Non-Hodgkin's Lymphoma
A Study of Atezolizumab in Combination With Either Obinutuzumab Plus Bendamustine or Obinutuzumab Plus (+) Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Participants With Follicular Lymphoma (FL) or Rituximab + CHOP in Participants With Diffuse Large B-Cell Lymphoma (DLBCL)
A Trial of Mosunetuzumab (BTCT4465A) as Consolidation Therapy in Participants With Diffuse Large B-Cell Lymphoma Following First-Line Immunochemotherapy and as Therapy in Participants With Previously Untreated Diffuse Large B-Cell Lymphoma Who Are Unable to Tolerate Full-Dose Chemotherapy
A Study Evaluating the Safety and Efficacy of Atezolizumab in Combination With Obinutuzumab Plus Lenalidomide in Patients With Relapsed or Refractory Follicular Lymphoma
A Study Evaluating Safety and Efficacy of Obinutuzumab, Polatuzumab Vedotin (Pola), and Atezolizumab (Atezo) in Participants With Relapsed or Refractory Follicular Lymphoma (FL) and Rituximab, Atezo, and Pola in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
A Clinical Trial to Investigate the Effect of a Short Duration Infusion of Obinutuzumab in Patients with Previously Untreated Advanced Follicular Lymphoma (MO40597 study)
Untreated FolliculaR Lymphoma Treated With OBinituzumAb in a Non-interventional Study (URBAN)
A clinical trial to compare how well treatment with polatuzumab vedotin plus rituximab plus gemcitabine plus oxaliplatin (Pola-R-GemOx) works in people with diffuse large B-cell lymphoma versus treatment with R-GemOx alone
A clinical trial to look at the safety and effectiveness of mosunetuzumab plus lenalidomide for treating follicular lymphoma
A study to look at whether longer rituximab treatment provides additional benefit in patients with non-Hodgkin lymphoma and whether this affects treatment safety (the MabCute study)
A clinical trial to look at whether RO7227166 combined with another treatment (either obinutuzumab or glofitamab) is safe and effective at different doses for patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma
A Study Evaluating the Safety and Efficacy of RO7082859 or Mosunetuzumab (RO7030816) in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma and High-Grade Large B-Cell Lymphoma
Utility Study in Diffuse Large B-Cell Lymphoma (DLBCL)
An Open-Label Phase lB Study of RO7082859 and Atezolizumab in Adult Patients With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
A study in patients with Non Hodgkin's lymphoma (GALLIUM)
A study for patients with Non-Hodgkin's Lymphoma (GOYA)
A Study to Evaluate the Safety, Pharmacokinetics, and Clinical Activity of the Combination of RO6870810 and Venetoclax, With or Without Rituximab, in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma
A Study of RO7082859 in Combination With Rituximab or Obinutuzumab Plus Chemotherapy in Participants With Non-Hodgkin Lymphomas
A Study of Polatuzumab Vedotin (DCDS4501A) in Combination With Rituximab or Obinutuzumab Plus Bendamustine in Participants With Relapsed or Refractory Follicular or Diffuse Large B-Cell Lymphoma
A Study of Obinutuzumab, Rituximab, Polatuzumab Vedotin, and Venetoclax in Relapsed or Refractory Follicular Lymphoma (FL) or Diffuse Large B-Cell Lymphoma (DLBCL)
A Study of Obinutuzumab, Polatuzumab Vedotin, and Lenalidomide in Relapsed or Refractory Follicular Lymphoma (FL) and Rituximab in Combination With Polatuzumab Vedotin and Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma
A Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Participants With B-Cell Non-Hodgkin Lymphoma
A Dose Escalation Study of RO7082859 as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer
A study to look at how safe different doses of the study medicine - DCDS0780A - were for patients with non-Hodgkin’s Lymphoma that involved B cells
A clinical trial to compare glofitamab plus chemotherapy with rituximab plus chemotherapy in people with diffuse large B-cell lymphoma (after previous treatment has not worked).
A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax Combined With Chemotherapy in Participants With B-Cell Non-Hodgkin's Lymphoma (NHL) and DLBCL
A Study to Evaluate Glofitamab as Single Agent Administered After Pretreatment With Obinutuzumab in Chinese Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
A Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versus Intravenous (IV) Rituximab, in Combination With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, Prednisone) in Previously Untreated Participants With CD20 Positive Diffuse Large B-Cell Lymphoma (DLBCL)
A clinical trial to compare the drug combination mosunetuzumab plus lenalidomide with the drug combination rituximab plus lenalidomide in people with previously treated follicular lymphoma
A Safety and Pharmacology Study of Atezolizumab (MPDL3280A) Administered With Obinutuzumab or Tazemetostat in Participants With Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma
A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax in Combination With Polatuzumab Vedotin Plus Rituximab (R) and Cyclophosphamide, Doxorubicin, Prednisone (CHP) in Participants With Untreated BCL-2 Immunohistochemistry (IHC)-Positive Diffuse Large B-Cell Lymphoma (DLBCL)
A clinical trial to look at how well glofitamab plus R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone) worked in people with ctDNA high-risk diffuse large B-cell lymphoma (DLBCL)
A study to evaluate the safety, tolerability, processing by the body, mechanism of action, and effectiveness of glofitamab following obinutuzumab pretreatment in patients with B-cell non-Hodgkin lymphoma
A Study Evaluating the Effects of the Body on and the Safety and Effectiveness of Mosunetuzumab in Patients with Relapsed or Refractory Follicular Lymphoma.
A clinical trial to compare mosunetuzumab plus polatuzumab vedotin with rituximab plus gemcitabine plus oxaliplatin in people with relapsed or refractory aggressive non-Hodgkin’s lymphoma
A clinical trial to test CC-220 or CC-99282 in combination with mosunetuzumab or glofitamab in people with B-cell non-Hodgkin lymphoma.
A clinical trial to look at how well RO7443904 and glofitamab work (when taken together) to treat people with relapsed or refractory Non-Hodgkin’s lymphoma, and how safe the combination is.
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab Monotherapy in Participants With Select B-Cell Malignancies
A clinical trial to look at how safe and effective mosunetuzumab plus tiragolumab, with or without atezolizumab, is for the treatment of relapsed or refractory B-cell non-Hodgkin lymphoma (NHL)
A clinical trial to examine the effectiveness and safety of glofitamab in combination with R-ICE (rituximab plus ifosfamide, carboplatin and etoposide) in people with relapsed or refractory (treatment-resistant) diffuse large B-cell lymphoma
A study to look at how safe was it to give people with blood cancer (non-Hodgkin’s lymphoma and chronic lymphocytic leukemia) – different doses of a study medicine (fenebrutinib)
A clinical trial to look at how well glofitamab works on its own, and in combination with standard cancer chemotherapy plus immunotherapy in children and young adults with B-cell non-Hodgkin lymphoma (B-NHL) after one or multiple standard therapies have not worked
A Study to Evaluate the Efficacy and Safety of Vismodegib in Combination With Ruxolitinib for the Treatment of Intermediate- or High-Risk Myelofibrosis (MF)
A Study of the Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
A Dose Escalation and Expansion Study of RO7121661, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumors
Endometrial Cancer
A clinical trial to look at how well atezolizumab plus chemotherapy works in women with endometrial cancer
A clinical trial to look at how well giredestrant works in people with Stage 1, Grade 1 endometrial cancer, how safe giredestrant is and to understand the way the body processes giredestrant
A Performance and Bioavailability Study of Entrectinib in Healthy Volunteers.
A study to look at the effectiveness of chemotherapy plus bevacizumab compared with chemotherapy alone in children and adolescents with metastatic soft tissue sarcoma (STS) (BERNIE)
A clinical trial to find a safe and suitable dose of idasanutlin, and to see how well idasanutlin works when given with chemotherapy or venetoclax, in children and young adults with leukemia or solid tumours
Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors
Solid Tumors
An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Preliminary Efficacy of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) in Pediatric and Young Adult Participants With Solid Tumors
A clinical trial to look at how safe RO7284755 is at different doses and how well RO7284755 alone or together with atezolizumab works to reduce solid tumours
A Study to Evaluate the Safety and Tolerability of RO7296682 in Participants With Advanced Solid Tumors.
A Study Of The Pharmacokinetics And Safety Of Ipatasertib In Chinese Participants With Locally Advanced Or Metastatic Solid Tumors.
A study of a medicine (GDC-0919) combined with another medicine (atezolizumab) in patients with cancer that has grown or spread
A study to look at how safe different doses of MOXR0916 were for patients with cancer – when combined with one or two other medicines
A Study of RO6958688 in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen Positive Solid Tumors
A clinical trial to understand how genetic testing can help doctors to decide which treatment is best for patients with solid tumours (TAPISTRY)
A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response
A Study to Evaluate the Safety and Tolerability of RO7296682 in Combination With Atezolizumab in Participants With Advanced Solid Tumors.
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations.
A clinical trial to look at how safe alectinib is, and how well it works in children and adolescents who have a solid tumor in the body or in the brain and/or spinal cord with a change in the ALK gene (called ALK gene fusion).
A Study to Evaluate Safety, Pharmacokinetics and Anti-Tumor Activity of RO7300490, as Single Agent or in Combination With Atezolizumab in Participants With Advanced Solid Tumors
A study to look at how safe different doses of atezolizumab were for patients – and how this medicine was processed through the body
RLY-1971 in Subjects With Advanced or Metastatic Solid Tumors
A study to look at how safe different doses of the study medicine (MOXR0916) were for patients with solid tumor cancer that had spread and did not respond to previous treatment(s), and how this medicine was processed by the body
A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test
A Study to Assess the Safety and Tolerability of Atezolizumab in Combination With Other Immune-Modulating Therapies in Participants With Locally Advanced or Metastatic Solid Tumors
An Extension Study in Participants Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella C)
A Study to Evaluate Safety, Pharmacokinetics, and Preliminary Anti-tumor Activity of RO7444973 in Participants With Unresectable and/or Metastatic MAGE-A4-positive Solid Tumors
A study to evaluate the safety, tolerability, processing by the body and effectiveness against BRAF-mutated solid tumours or melanoma of RO7276389 by itself or in combination with cobimetinib
 A study to evaluate the use of a smartphone application and biosensor by cancer participants undergoing systemic treatments.
Screening Study for Participants With Malignant Tumors
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
A Phase I, Open-label, Non-randomized Study to Characterize the Impact of Dietary Modification on Inavolisib Associated Hyperglycemia and to Assess the CYP3A4 Induction Potential of Inavolisib using Midazolam as a Probe Substrate in Patients with Incurable Metastatic Solid Tumors Previously Treated with Multiple (≥2) Lines of Therapy
A clinical trial to test the safety of tiragolumab and atezolizumab when combined and given from a single bottle, and to understand the way the body processes these drugs in people with cancer that has advanced in nearby cells (locally advanced), has come back (recurring), or that has spread to other parts of the body (metastatic)
Observational Study Evaluating Rituximab Use and Use of the Patient Alert Card in Participants Receiving Rituximab Infusion for a Non-Oncology Indication at Infusion Centers in Europe
Thymic Carcinoma
A Study to Investigate the Efficacy and Safety of Atezolizumab (Tecentriq) in Previously-Treated Patients With Advanced Thymic Carcinoma
Glioma de alto grado
A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Adolescent Participants With High-Grade Glioma
Esophageal Squamous Cell Carcinoma
A clinical trial to evaluate the safety and effectiveness of atezolizumab with or without tiragolumab versus placebo in people with squamous cell esophageal cancer that cannot be surgically removed and has not got worse after prior chemoradiotherapy (SKYSCRAPER-07)
Cancer de l'oesophage
A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma
Melanoma
A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Atezolizumab in Patients With NRAS-mutant Advanced Melanoma.
A clinical trial to look at how well treatment combinations work in people with melanoma (Morpheus-Melanoma)
A clinical trial to compare the effectiveness and safety of different doses of RO7247669 in people with melanoma that cannot be removed by surgery or has spread to other organs
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
A clinical trial to compare bevacizumab and atezolizumab, cisplatin and gemcitabine with atezolizumab, cisplatin and gemcitabine in people with untreated biliary tract cancer
Thyroid Cancer
A clinical trial to compare pralsetinib with standard-of-care treatment (cabozantinib or vandetanib) in people with RET-mutated medullary thyroid cancer (RET-MTC)
Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Patients With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
Rectal Cancer
A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemotherapy in Participants With Locally Advanced Rectal Cancer
Glioblastoma
A Study Evaluating the Safety, Pharmacokinetic and Anti-tumor Activity of RO7428731 in Participants With Glioblastoma
Gastric and Gastroesophageal Junction Carcinoma
An Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Gastric or Gastroesophageal Junction Carcinoma
A study exploring the safety and efficacy of Atezolizumab in combination with Obinutuzumab or Rituximab anti-CD20 therapy in participants with Relapse/Refractory Marginal Zone Lymphoma (MZL), Mantle Cell Lymphoma (MCL) and Waldenström Macrobulinemia (WM)
How does the body process a cancer medicine (pralsetinib) – when it is taken together with another medicine (cyclosporine)
A clinical trial to see if a patient monitoring app can help improve health outcomes in people who are being given anti-cancer treatment
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
Autoimmune Disorder
Giant Cell Arteritis
An Extension Study to Evaluate Long-Term Safety of Subcutaneous (SC) Tocilizumab in Participants With Giant Cell Arteritis (GCA)
A study for patients with Giant Cell Arteritis (GCA)
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA).
Juvenile Idiopathic Arthritis
A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)
A Study of Subcutaneously (SC) Administered Tocilizumab (TCZ) in Participants With Polyarticular-Course Juvenile Idiopathic Arthritis (pJIA)
A Study of Subcutaneously Administered Tocilizumab in Participants With Systemic Juvenile Idiopathic Arthritis
Extension Study Evaluating the Safety and Efficacy of Subcutaneous Tocilizumab (RoActemra/Actemra) Administration in Systemic and Polyarticular-Course Juvenile Idiopathic Arthritis
Rheumatoid Arthritis
A Study of the Efficacy and Safety of Tocilizumab for Confirmed Rheumatoid Arthritis (RA) Participants in Clinical Practice
A study of long-term effects of fenebrutinib treatment in patients with rheumatoid arthritis
A Study to Evaluate the Use of Glucocorticoids in Combination With Tocilizumab in Daily Clinical Practice
An Efficacy and Safety Study of Subcutaneous Tocilizumab in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Participants With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current Disease-Modifying Antirheumatic Drug (DMARD) Therapy
Non-Interventional Study of Tocilizumab Subcutaneous (SC) Monotherapy in Participants With Rheumatoid Arthritis (RA)
Study of Tocilizumab (RoActemre) Administered Subcutaneously in Participants With Rheumatoid Arthritis in Everyday Clinical Practice
Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis Participants
Tocilizumab Real-Life Human Factors (RLHFs) Validation Study
A Comparative Study to Observe the Effect of Concomitant Use of Corticosteroid Treatment in Rheumatoid Arthritis (RA) Participants Who Are Treated With a Tumor Necrosis Factor (TNF) Inhibitor or Tocilizumab (TCZ) as Their Second Biological Treatment.
Safety and Efficacy Study of GDC-0853 Compared With Placebo and Adalimumab in Participants With Rheumatoid Arthritis (RA)
EMBRACE-SC: Observational Study of Subcutaneous (SC) Tocilizumab Alone or in Combination With Conventional Disease-Modifying Antirheumatic Drugs (cDMARDs) in Rheumatoid Arthritis
Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) Treatment
Study to Describe Real World Drug Retention Rate of the Tocilizumab at One Year
A Time to Cardiovascular Event Analysis Comparing Tocilizumab to Other Biologics in Patients With Rheumatoid Arthritis (RA)
Sjogren's Syndrome
A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome
Ulcerative Colitis
A Phase I Study Of Etrolizumab Followed By Open-Label Extension And Safety Monitoring In Pediatric Patients With Moderate To Severe Ulcerative Colitis Or Moderate To Severe Crohn’s Disease
A study to look at a new medicine called “UTTR1147A” - how safe are different doses for healthy people and patients to take – and how is this medicine processed through the body
A Clinical Trial to Compare Etrolizumab with Infliximab in Patients with Moderate to Severe Ulcerative Colitis Who Have not Received Treatment with Tumour Necrosis Factor Inhibitors (Gardenia)
A Clinical Trial to Compare Etrolizumab with Placebo and Adalimumab in Patients with Moderate to Severe Ulcerative Colitis Who Have not Received Treatment with Tumour Necrosis Factor Inhibitors (Hibiscus I)
A Study of the Efficacy and Safety of Etrolizumab in Ulcerative Colitis Participants Who Have Been Previously Exposed to Tumor Necrosis Factor (TNF) Inhibitors
How does a new medicine (efmarodocokin alfa) compare to available medicine and placebo – in people with ulcerative colitis
Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies
A Study of the Efficacy and Safety of Etrolizumab Treatment in Maintenance of Disease Remission in Ulcerative Colitis (UC) Participants Who Are Naive to Tumor Necrosis Factor (TNF) Inhibitors
An Extension Study to Evaluate the Long-Term Safety and Tolerability of UTTR1147A in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease
A study in the use of etrolizumab in patients with ulcerative colitis (Eucalyptus)
A Clinical Trial to Compare Etrolizumab with Placebo and Adalimumab in Patients with Moderate to Severe Ulcerative Colitis Who Have not Received Treatment with Tumour Necrosis Factor Inhibitors (Hibiscus II)
A study to evaluate the safety, tolerability, processing by the body and mechanism of action of RO7486967 in participants with ulcerative colitis
Crohn's Disease
A Clinical Trial of Etrolizumab for Patients with Moderately to Severely Active Crohn's Disease (Bergamot)
A Study to Investigate the Pharmacokinetics, Pharmacodynamic Effects, Safety and Tolerability of Repeated Dosing of RO5459072 in Volunteers With Celiac Disease
Systemic Lupus Erythematosus
A study to compare different doses of fenebrutinib with a “placebo” – in patients with lupus
A clinical trial to look at how well obinutuzumab works to reduce certain features of systemic lupus erythematosus (SLE) when compared to placebo
A clinical trial to compare different doses of mosunetuzumab in people with systemic lupus erythematosus (SLE)
A clinical trial to look at how safe different doses of RO7507062 are in people with systemic lupus erythematosus and how the body processes this drug
A study of the long-term effects of fenebrutinib treatment in patients with lupus
The Mycophenolate Pregnancy Registry
A study to look at the effects of a new medicine (astegolimab) in comparison to placebo - in patients with eczema (atopic dermatitis)
Systemic Sclerosis
A Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis (SSc) (FocuSSced)
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of RO7303509 in Participants With Systemic Sclerosis
A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis
Inflammatory Bowel Disease (IBD)
An Observational Study to Assess the Relationship Between Disease Flare States and Patient-Reported Health Data, Health Data from a Wearable Activity Tracker, and Biomarker Data Obtained Through a Decentralized Process in Patients with Inflammatory Bowel Disease
A study to find out how safe is it to give people a new medicine called “GDC-8264” – including the effect of food on GDC-8264, and the effect of combining GDC-8264 with other medicines
A Phase Ia, Randomized, Investigator- and Subject-Blinded, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single-Ascending Doses of RO7490677 in Healthy Volunteers
Granulomatosis With Polyangiitis
A Phase IIa Study of Intravenous Rituximab in Pediatric Participants With Severe Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis
A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV)
Lupus Nephritis
A clinical trial to look at how well obinutuzumab works in treating people with lupus nephritis and how safe it is (REGENCY)
A Study to Evaluate the Safety and Efficacy of Obinutuzumab Compared With Placebo in Participants With Lupus Nephritis (LN)
A clinical trial to compare obinutuzumab with placebo in adolescents with lupus nephritis (POSTERITY)
A Phase I, multicenter, single-arm study to evaluate the pharmacokinetics, pharmacodynamics, and safety of crovalimab in patients with lupus nephritis
Neuromyelitis optica spectrum disorders
Efficacy and Safety Study of Satralizumab (SA237) as Monotherapy to Treat Participants With Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD)
Efficacy and Safety Study of Satralizumab (SA237) as Add-on Therapy to Treat Participants With Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD)
A clinical trial to look at the long-term safety and effects of satralizumab in people with neuromyelitis optica spectrum disorder.
A clinical trial to look at how effective and safe satralizumab is for treating people with neuromyelitis optica spectrum disorder (NMOSD)
Paroxysmal Nocturnal Hemoglobinuria
A clinical trial to compare the effectiveness and safety of crovalimab with eculizumab in people with paroxysmal nocturnal hemoglobinuria (PNH)
A clinical trial to compare the safety and effectiveness of crovalimab with eculizumab in people with paroxysmal nocturnal hemoglobinuria (PNH) not currently treated with complement inhibitors
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibition
Primary Membranous Nephropathy
A clinical trial to compare obinutuzumab with tacrolimus in people with a kidney disease called primary membranous nephropathy.
Autoimmune Hepatitis (AIH)
Effect of RO7049665 on the Time to Relapse Following Steroid Tapering in Participants With Autoimmune Hepatitis (AIH)
Myasthenia Gravis (IAB)
A clinical trial to look at how safe and effective satralizumab is at reducing certain signs of generalised myasthenia gravis (gMG)
MOG Antibody Disease
A clinical trial to compare satralizumab to placebo, with or without background therapy, in people with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
Autoimmune Encephalitis
A clinical trial to compare satralizumab with placebo in people with autoimmune encephalitis
Guillain-Barré Syndrome
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps
An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
Eye Disorder
Glaucoma
A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO5093151 in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT).
Age-Related Macular Degeneration
A study to look at how safe a study medicine was for patients – when taken at different doses - and how this medicine was processed through the body
A Study in Patients With Neovascular Age Related Macular Degeneration or Macular Edema Secondary To Retinal Vein Occlusion to Evaluate Usability of the Ranibizumab (Lucentis®) Prefilled Syringe (PFS)
Long-Term Safety of Lampalizumab Intravitreal (ITV) Injections in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OMASPECT)
A Clinical Trial to Test an Ocular Implant that Releases Ranibizumab Compared with Eye Injections of Ranibizumab in Patients with Wet Age-Related Macular Degeneration (Archway)
Study to Evaluate Faricimab (RO6867461; RG7716) for Extended Durability in the Treatment of Neovascular Age Related Macular Degeneration (STAIRWAY)
A Clinical Trial to Assess the Long-Term Safety and Tolerability of a New Eye Implant to Give Ranibizumab to Patients with Neovascular Age-Related Macular Degeneration (Portal)
Study of the Efficacy and Safety of the Ranibizumab Port Delivery System for Sustained Delivery of Ranibizumab in Patients With Subfoveal Neovascular Age-Related Macular Degeneration (LADDER)
Study of RO7250284 in Participants With Neovascular Age-Related Macular Degeneration
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravitreal Injections of RO7303359 in Participants With Geographic Atrophy.
A study to test an eye implant that continuously releases ranibizumab, and is refilled either every 6 months or every 9 months in patients with wet age-related macular degeneration (wet AMD) (Velodrome)
A clinical trial to look at the long-term safety of faricimab in patients with neovascular age-related macular degeneration (nAMD, also known as wet AMD)
A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age‑Related Macular Degeneration (AMD) (AVENUE)
A clinical trial to evaluate maintenance of vision after switching to treatment with an eye implant containing ranibizumab in participants with neovascular age-related macular degeneration
A study to evaluate the long-term safety and tolerability of faricimab administered in patients previously enrolled in Roche-sponsored studies
An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration
Wet Age-Related Macular Degeneration
A clinical trial to compare faricimab with aflibercept in people with neovascular age-related macular degeneration. (Tenaya)
A clinical trial to compare faricimab with aflibercept in people with neovascular age-related macular degeneration. (Lucerne)
Retinal Vein Occlusion
A clinical trial to compare the experimental treatment faricimab with the approved medicine aflibercept in people with macular oedema due to blockage of at least one branch of the retinal blood vessels within the eye
A clinical trial to compare faricimab with aflibercept in people with macular oedema due to blockage of the central (main) retinal vein or the hemiretinal vein (main branch of the smaller blood vessels) within the eye
Neovascular Age-related Macular Degeneration
A Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate the Safety of the Faricimab Prefilled Syringe
A Study Of The Efficacy, Safety, And Pharmacokinetics Of The Port Delivery System With Ranibizumab In Chinese Patients With Neovascular Age-Related Macular Degeneration
Polypoidal Choroidal Vasculopathy (PCV)
A Phase IIIb/IV, multicentre, open-label, single-arm study to investigate the efficacy and safety of faricimab (RO6867461) in patients with polypoidal choroidal vasculopathy
Dry Macular Degeneration
A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Uveitic Macular Edema
A clinical trial to look at how well RO7200220 works to improve vision compared with a sham treatment in people with inflammation-related fluid swelling in the eye (uveitic macular edema), and how safe RO7200220 is at different doses
A clinical trial to look at how well RO7200220 works to improve vision compared with a sham treatment in people with inflammation-related fluid swelling in the eye (uveitic macular edema), and how safe RO7200220 is at different doses
Muscle And Peripheral Nerve Disease
Duchenne Muscular Dystrophy
Clinical Trial to Evaluate the Efficacy, Safety, and Tolerability of RO7239361 in Ambulatory Boys With Duchenne Muscular Dystrophy
A Gene Transfer Therapy Study to Evaluate the Safety of SRP-9001 (Delandistrogene Moxeparvovec) in Participants With Duchenne Muscular Dystrophy (DMD)
Muscular Dystrophy
Study of an Investigational Drug, RO7239361 (BMS-986089), in Ambulatory Boys With DMD
Facioscapulohumeral Muscular Dystrophy (FSHD)
A clinical trial to compare RO7204239 with placebo in people with facioscapulohumeral muscular dystrophy
Infectious Diseases
Hepatitis B Virus
A Double-Blind Single-Ascending Dose (SAD) and Multiple-Ascending Dose (MAD) Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7049389 in Healthy Chinese Participants
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of RO7062931in Healthy Volunteers and Subjects With Chronic Hepatitis B
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7049389 in Healthy Volunteers and Chronic Hepatitis B Virus (HBV) Infected Participants
A Study in Healthy Volunteers and in Participants With Chronic Hepatitis B to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7020531
A Study of Pegylated Interferon Alfa-2A in Combination With Lamivudine or Entecavir Compared With Untreated Control Group in Children With Hepatitis B Envelope Antigen (HBeAg)-Positive Chronic Hepatitis B (CHB) in the Immune-Tolerant Phase
A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B
Influenza
A Pharmacokinetic/Pharmacodynamic Study of Oseltamivir in Immunocompromised Children With Confirmed Influenza Infection
A study to look at the safety and effectiveness of baloxavir marboxil in treating children with influenza aged between 1 and <12 years (miniSTONE-2)
Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants From Birth to < 1 Year With Influenza-Like Symptoms
A Study of MHAA4549A as Monotherapy for Acute Uncomplicated Seasonal Influenza A in Otherwise Healthy Adults
Study to Assess Efficacy and Safety of Baloxavir Marboxil In Combination With Standard-of-Care Neuraminidase Inhibitor In Hospitalized Participants With Severe Influenza
A clinical trial to look at how well baloxavir reduces the spread of the flu within households, compared with a placebo (no active treatment).
Bacterial Infection
A Study to Investigate the Intrapulmonary Lung Penetration of Nacubactam in Healthy Participants
A Study to Investigate the Pharmacokinetics of RO7079901 and Meropenem in Participants With a Complicated Urinary Tract Infection
A study to look at how safe different doses of a new medicine called “DSTA4637S” were for patients – and how this medicine was processed through the body
A Multicenter, Single-Dose, Uncontrolled, Open-label, One Group Study to Investigate the Pharmacokinetics of RO7223280 in Critically Ill Patients With Bacterial Infections
A Study to Investigate the Pharmacokinetics of RO7223280 in Critically Ill Participants With Bacterial Infections
A multiple-center, non-randomized, open-label study to investigate the effect of various degrees of renal impairment on the pharmacokinetics of a single intravenous dose of RO7223280
A study to compare different doses of fenebrutinib with a “placebo” – in patients with an autoimmune disease called “chronic spontaneous urticaria”
A study of long-term effects of fenebrutinib treatment in patients with chronic spontaneous urticaria
Hepatitis C Virus
COVID-19 Pneumonia
A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia
A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia
A Study to Evaluate the Efficacy and Safety of Tocilizumab in Hospitalized Participants With COVID-19 Pneumonia
A study to find out if a new medicine (either astegolimab or efmarodocokin alfa) was safe and effective in patients with severe COVID-19 pneumonia
A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia
Study to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19
A clinical trial to compare the safety and effectiveness of AT-527 with placebo in people with mild or moderate COVID-19
A clinical trial to observe patients with a diagnosis of COVID-19, who have previously taken part in an AT-527 COVID-19 clinical trial
A clinical trial to look at the safety and activity of tocilizumab in children and adolescents with COVID-19
Chronic Hepatitis B
A clinical trial to look at the safety and effectiveness of RO7565020 at different doses and how the body processes RO7565020 in healthy people and those with hepatitis B
A phase I, randomized, double-blind, multiple-ascending-dose study to evaluate the safety and pharmacokinetics of GDC-5780 in healthy subjects
A sponsor-open, randomized, placebo-controlled, phase I study to investigate the pharmacokinetics, safety, and tolerability of RO7223280 in healthy Chinese participants following single IV dose administration
Neurodegenerative Disorders
Alzheimer's Disease
A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD)
A Study of RO7105705 in Healthy Participants and Participants With Mild-to-Moderate Alzheimer's Disease
A Study to Evaluate the Efficacy and Safety of RO7105705 in Patients With Prodromal to Mild Alzheimer's Disease
An Open-Label Crenezumab Study in Patients With Alzheimer's Disease
Evaluation of [18F]RO6958948 as Tracer for Positron Emission Tomography (PET) Imaging of Tau Burden in Alzheimer's Disease Participants
Longitudinal Evaluation of [18F]GTP1 as a PET Radioligand for Imaging Tau in the Brain of Participants With Alzheimer's Disease Compared to Healthy Participants
CREAD Study: A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD)
A Study of MTAU9937A in Patients With Moderate Alzheimer's Disease
A Study of Gantenerumab in Participants With Mild Alzheimer Disease
A Study of Gantenerumab in Participants With Prodromal Alzheimer's Disease
Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's Disease
A clinical trial to look at the long-term effects of gantenerumab in people with Alzheimer’s disease
A clinical trial to look at the safety and effects of long-term treatment with gantenerumab in people with Alzheimer's disease
A Study of the Biodistribution and Safety of [18F]GTP1 in Healthy Japanese Participants
Evaluation Comparing Two Tau PET Radiotracers, [18F]PI-2620 and [18F]GTP1, in Brains of Participants With Prodromal or Mild Alzheimer's Disease
Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease
A Study of Crenezumab in Participants With Mild to Moderate Alzheimer Disease
Amyotrophic Lateral Sclerosis
A study to look at a new medicine called, “GDC-0134”, for treating patients with amyotrophic lateral sclerosis (ALS)
Bioavailability of GDC-0134 and the Effect of Food and Proton Pump Inhibitor on Pharmacokinetics of GDC-0134 in Healthy Female Participants
Parkinson's Disease
A study to evaluate whether Prasinezumab can slow or halt disease progression in people with a recent diagnosis of Parkinson’s disease.
A study to evaluate whether prasinezumab can slow down certain signs of Parkinson’s disease (PD) progression compared to placebo, and how safe prasinezumab is, in people already treated for symptoms of Parkinson’s disease.
A phase 1b, adaptive, multi-center, randomized, double-blind, placebo-controlled, parallel design study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of RO7486967 in participants with early idiopathic Parkinson's disease
Multiple Sclerosis
Monitoring of Multiple Sclerosis (MS) Participants With the Use of Digital Technology (Smartphones and Smartwatches) - A Feasibility Study
Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Participants With Early Stage Relapsing Remitting Multiple Sclerosis (RRMS)
Participants Preferences to Disease Modifying Agents in Relapsing Remitting Multiple Sclerosis Condition
This is an Extension Study of the Roche P-trial to Investigate Safety and Effectiveness of a Single Ocrelizumab Dose in Participants With Multiple Sclerosis (MS)
A Study to Evaluate the Safety of Administering Ocrelizumab Per a Shorter Infusion Protocol in Participants With Primary Progressive Multiple Sclerosis (PPMS) and Relapsing Multiple Sclerosis (RMS).
A Clinical Trial of Ocrelizumab in Patients with Progressive Multiple Sclerosis (CONSONANCE)
A study of ocrelizumab in patients with multiple sclerosis (MuSicalE)
Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)
A Study to Provide Complementary Efficacy, Safety and Patient Reported Outcomes Data in Participants With Active Relapsing Forms of Multiple Sclerosis (MS) in a Pragmatic Setting
A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
A Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administration In Patients With Multiple Sclerosis
A clinical trial to find a safe and suitable dose of ocrelizumab in children and adolescents with relapsing-remitting multiple sclerosis
A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
Study to Assess Disease Activity and Biomarkers in Minority Participants With Relapsing Multiple Sclerosis (RMS) Before and During Treatment With Ocrelizumab
A Study to Evaluate the Effects of Ocrelizumab on Immune Responses In Participants With Relapsing Forms of Multiple Sclerosis
A clinical trial to look at the safety and effectiveness of a higher dose of ocrelizumab to treat patients with relapsing multiple sclerosis.
A clinical trial to compare fenebrutinib with ocrelizumab in people with primary progressive multiple sclerosis (PPMS)
A clinical trial to look at the safety and effectiveness of a higher dose of ocrelizumab to treat patients with primary progressive multiple sclerosis.
A clinical trial to compare fenebrutinib with teriflunomide in people with relapsing multiple sclerosis (RMS)
A clinical trial to compare fenebrutinib with teriflunomide in people with relapsing multiple sclerosis (RMS)
A Study of Ocrelizumab in Participants With Primary Progressive Multiple Sclerosis
A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis
A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy
A Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumab
A clinical trial to investigate the effectiveness of fenebrutinib compared with placebo in people with relapsing multiple sclerosis.
A clinical trial to compare the safety and effectiveness of ocrelizumab with fingolimod in children and young people with relapsing-remitting multiple sclerosis (RRMS)
Impact of ocrelizumab on patient-reported fatigue and quality of life in patients with relapsing multiple sclerosis treated for the first time with ocrelizumab
A study to evaluate specific unmet needs in the current clinical practice of multiple sclerosis
A study to investigate the concordance of smartphone-based self-monitoring, imaging, and blood-based biomarkers with clinical disability in participants with multiple sclerosis (MS)
A clinical trial to test the safety of RO7121932 at different dose levels in people living with multiple sclerosis; determine how well it is tolerated by trial participants; measure how the body absorbs, distributes, and gets rid of it; and find out what effects, good or bad, RO7121932 has on trial participants.
A Study To Determine The Effect Of Ocrelizumab On Leptomeningeal Inflammation In Multiple Sclerosis
A clinical trial to examine if an injection of ocrelizumab under the skin is a safe and effective alternative way of treating patients with multiple sclerosis (MS)
A prospective investigation of the feasibility of smartphone-based self-monitoring to characterize cognitive and neurological impairment in patients with multiple sclerosis (Floodlight MS_More Active)
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
A randomized, double-blind, placebo-controlled study to investigate the efficacy of fenebrutinib in relapsing multiple sclerosis
A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous RO7121932 in Participants With Multiple Sclerosis
Huntington's Disease
A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Patients With Manifest Huntington's Disease
Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease
BN40697 - A study to look at tominersen safety over 15 months in people with Huntington’s disease
An Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of RO7234292 (RG6042) in Patients With Huntington's Disease
A Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and Safety and Tolerability Following Intrathecal Administration in Patients With Huntington's Disease
A clinical trial to compare different doses of tominersen with a placebo in people with prodromal (very early subtle signs) and early manifest Huntington’s disease
Relapsing Multiple Sclerosis (RMS)
A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis
Study to characterize access to specialty care received by American Indians/Alaska Natives (CATORI)
Neurodevelopmental Disorder
Autism Spectrum Disorder
A Clinical Trial of Balovaptan in Adults with Autism Spectrum Disorder (V1ADUCT)
A Study to Investigate the Efficacy and Safety of RO5285119 in Participants With Autism Spectrum Disorder (ASD)
Open Label, Adaptive, Parallel Group PET Study Using RO7017773 And [11C] RO15-4513
A Study to Evaluate Scales for Repetitive and Restricted Behaviors in Children, Adolescents, and Adults With Autism Spectrum Disorder (ASD)
A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (VANILLA)
A Study to Investigate the Effect of Esomeprazole and the Effect of Food on the Pharmacokinetics of Balovaptan in Healthy Volunteers
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants
Autism
A clinical trial to compare different doses of an investigational drug (called ‘RO7017773’) with a placebo (a pretend drug) in people with Autism Spectrum Disorder
Angelman Syndrome
A Study To Investigate The Safety Of RO7248824 in Children With Angelman Syndrome And To Understand The Way The Body Processes The Investigational Therapy
A Study To Assess Distribution Of RO7248824 In The Central Nervous System Following Single Intrathecal Doses Of [89zr] Labeled RO7248824 In Healthy Male Participants
A 12-week study to investigate how the body handles alogabat once it is swallowed, how safe it is, and whether it could be effective in treating the symptoms of AS.
A study to investigate the effect of enzyme inhibition on the bodily processing of RO6953958 in healthy participants
Dup15q Syndrome
A clinical trial to compare the effects of basmisanil with a placebo in children with Dup15q syndrome
Psychiatric Disorder
Schizophrenia
A Study to Evaluate the Effects of Basmisanil in Participants With Cognitive Impairment Associated With Schizophrenia (CIAS) Treated With Antipsychotics
A Study to Evaluate The Effects of RO5545965 in Participants With Negative Symptoms of Schizophrenia Treated With Antipsychotics
A study of patients with Schizophrenia (FlashLyte)
A study to evaluate the safety, tolerability, processing by the body and mechanism of action of multiple doses of ralmitaront with a single dose of risperidone administered to healthy participants
Post Traumatic Stress Disorder
Study To Evaluate The Efficacy And Safety Of Balovaptan In Adults With Post-Traumatic Stress Disorder (PTSD)
Respiratory Disorder
Idiopathic Pulmonary Fibrosis
A Study of Oral Vismodegib in Combination With Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis
A Study to Characterize the Disease Behavior of Idiopathic Pulmonary Fibrosis (IPF) and Interstitial Lung Disease (ILD) During the Peri-Diagnostic Period
Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Risk of Group 3 Pulmonary Hypertension
Open-label Study to Assess the Effectiveness of Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis (IPF).
Quality of Life Study in Participants With IPF Under Pirfenidone Treatment
Safety and Tolerability Study of Pirfenidone in Combination With Nintedanib in Participants With Idiopathic Pulmonary Fibrosis (IPF)
A Study to Evaluate the Efficacy and Safety of PRM-151 in Patients With Idiopathic Pulmonary Fibrosis
A Phase 1 Double-Blind, Randomized, Two-Arm, Two-Way Crossover, Sequential Two-Stage Study to Assess the Pharmacokinetic Comparability of First and Second Generation RO7490677 (Recombinant Human Pentraxin-2; rhPTX-2) Drug Products in Healthy Subjects
A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease
Asthma
A Study to Investigate the Safety, Pharmacokinetics, and Immunogenicity of BITS7201A in Healthy Volunteers and Participants With Mild Atopic Asthma
A study to compare different doses of MSTT1041A with a “placebo” – in patients with severe asthma
A study to find out if a new medicine – MTPS9579A – works in people with asthma
A study to find out if a new medicine, GDC-0214, is safe in healthy people and in patients with asthma
A study to find out how safe is it to give people with asthma a new medicine called MTPS9579A
A Study of Pirfenidone in Patients With Unclassifiable Progressive Fibrosing Interstitial Lung Disease
A Safety Study of Balsamic Bactrim in Pediatric Participants With Acute Bronchitis
A Non-Interventional Safety Study of Balsamic Bactrim
Chronic Obstructive Pulmonary Disease
A Study Of ¹²⁹XE MRI To Assess Disease Progression In Patients With COPD Treated With Or Without Azithromycin And Standard-of-Care Medications
A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
A study to assess the safety of RO7486967 in patients with chronic obstructive pulmonary disease
A clinical trial to see how well different doses of astegolimab plus standard treatment work compared with a placebo plus standard treatment to reduce certain symptoms of chronic obstructive pulmonary disease
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
Unexplained Chronic Cough
A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamic Effects Of GDC-6599 In Patients With Chronic Cough
Healthy Volunteers
A Study to Evaluate the Bioequivalence of Tocilizumab Following Subcutaneous Administration Via an Autoinjector (AI 1000-G2) Versus a Pre-Filled Syringe in Healthy Volunteers
A Drug-Drug Interaction Study Between GDC-0853 and Midazolam, Itraconazole, Rosuvastatin, and Simvastatin
A study to look at how safe different doses of GDC-0334 were for healthy people and how this medicine was processed through the body
Assess the Safety and Tolerability of Single and Multiple Ascending Doses of Oral RO7020531 in Chinese Healthy Participants
A Pharmacokinetic Study of [14C]-GDC-0810 After Single Oral Administration in Healthy Female Participants
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7079901 and the Combination of RO7079901 With Meropenem in Adult Healthy Volunteers
Relative Bioavailability of Gantenerumab Produced by G4 Process Versus G3 Process Following Subcutaneous (SC) Injection in Healthy Participants
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GDC-0853 in Healthy Japanese and Caucasian Participants
A Study to Investigate the Effect of Formulation, Food, and Rabeprazole on the Pharmacokinetics (PK) of GDC-0853 in Healthy Participants
A Study to Evaluate the Effect of a Potent Cytochrome P450 (CYP) 3A Inhibitor on Ipatasertib
A Study to Assess the Impact of Speed and Site of Subcutaneous Injection on Pain, Tolerability, Safety, and Pharmacokinetics of Gantenerumab in Healthy Participants
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7034067 in Healthy Japanese Participants
A Study to Compare Pharmacokinetics (PK) of Etrolizumab Administered Subcutaneously by a Prefilled Syringe With Needle Safety Device (PFS-NSD) or an Auto-injector (AI)
The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RO6889450 in Healthy Volunteers
A Single-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics (PK) of Gantenerumab Following Subcutaneous (SC) Administration in Healthy Volunteers
A Study to Evaluate Pain, Tolerability, Safety, and Usability of a Single Self-administered Etrolizumab by Auto-injector in Healthy Participants
Study to Investigate the Effect of Formulation and Food on the Pharmacokinetics of GDC-0810
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7049665 in Healthy Volunteers
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers.
Study Investigating a Single Oral Dose of Fenebrutinib in Healthy Volunteers
Study to Assess Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of RO7112689 in Healthy Volunteers and Participants With Paroxysmal Nocturnal Hemoglobinuria
A Study to Investigate the Effect of Rifampicin on the PK of Multiple Doses of Balovaptin In Healthy Volunteers
A Study to Investigate the Effect of Itraconazole on the PK of Multiple Doses of Balovaptan in Healthy Volunteers
Compare Bioavailability of BMS-986089 After Subcutaneous Injection
A Study Investigating the Excretion Balance, Pharmacokinetics and Metabolism of a Single Oral Dose of [14C]-Labeled RO7034067 in Healthy Male Participants
A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Emicizumab in Healthy Chinese Volunteers
A Study to Investigate the Effect of RO7049389 on the Pharmacokinetics of Pitavastatin in Healthy Volunteers
A Study Investigating the Absolute Oral Bioavailability of Balovaptan After Single and Multiple Daily Oral Doses of Balovaptan in Healthy Volunteers
A Study to Investigate the Effect of CYP3A Inhibition on the Pharmacokinetics of RO7017773 in Healthy Participants
A Study to Investigate the Relative Bioavailability of Entrectinib Capsule Formulations F1 and F06 Under Fed Conditions in Healthy Participants
A study to find out if people get the same amount of medicine when they take the two different forms.
Study to Investigate the Effect of Balovaptan on the QTC Interval in Healthy Subjects
A study to find out if taking different forms of GDC-0134 gives you the same amount of medicine in your body
A 2 Part Study to Assess the Relative Bioavailability of Tablet Formulation Compared to Capsule Formulation and the Effect of Food and Taste Assessment on the Tablet Formulation in Healthy Participants
Study to Assess the Pharmacokinetics, Safety and Tolerability of Baloxavir Marboxil in Healthy Chinese Participants
A study to find out if taking different forms of a medicine (GDC-9545) results in the same amount of medicine in your body – and the effect of food on the medicine
A Single Ascending Dose Study to Investigate the Safety, Tolerability, Immunogenicity and Pharmacokinetics of Intravenously Administered RO7126209 in Healthy Participants
A study to look at how safe different doses of a new medicine called MTPS9579A were for healthy people to take, and how this medicine was processed through the body
A Study To Investigate The Safety, Tolerability And Pharmacokinetics (PK) Of RO7223280 Following Intravenous Administration In Healthy Participants
A study to find out what happens to a new medicine inside women’s bodies – and to look at different forms of the medicine (giredestrant)
Mass Balance and Absolute Bioavailability Study of RO7049389 in Healthy Volunteers
A study to evaluate the safety, tolerability, processing by the body, and antitumor activity of inavolisib and paclitaxel with or without targeted therapies
A study to investigate the processing by the body, safety, and side effects of gantenerumab in healthy Chinese participants following a single dose
A study to find out how safe is it to give people a new medicine for asthma (GDC-4379), and to see how this medicine is processed in the body
A study to evaluate the safety, tolerability, processing by the body, and response of the body to the drug RO7497987 in single and multiple ascending doses in healthy volunteers
A study to compare low-volume blood sampling techniques versus conventional blood collection from veins to evaluate drug concentration profiles after administration of a single dose of various study drugs in healthy subjects
A study to find out if people get the same amount of medicine (alectinib) - when they take different forms of the medicine - with or without food.
A Phase I randomized, investigator/participant-blind, adaptive, single ascending dose, placebo-controlled study to investigate the safety, tolerability, pharmacokinetics, and food effects of RO7308480 following oral administration in healthy participants
A Phase I, Randomized, Double-Blind, Single Ascending Dose Study to Evaluate the Safety and Pharmacokinetics of GDC-5780 in Healthy Subjects 
A Study in Healthy Male Subjects to Investigate the Comparability of Pharmacokinetics of the Fixed-Dose Combination of Pertuzumab and Trastuzumab Administered Subcutaneously Using a Handheld Syringe or Using the On-Body Delivery System
A non-randomized, open-label, single-dose study to investigate the intrapulmonary penetration of RO7223280 following intravenous administration in healthy participants
Open-label, non-randomized study investigating the excretion balance, pharmacokinetics, and metabolism of a single intravenous dose of [14C]-labelled RO7223280 in healthy male participants
A Phase Ib, Randomized, Double-blind, Placebo-controlled, Single-center Study to Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of GDC-6988 With and Without Albuterol Pretreatment in Healthy Adult Subjects
A Two-Part, Open-Label, Comparative, Single-Dose, Randomized, Five-Treatment, Three-Way Crossover Sequential Study to Assess the Relative Bioavailability of Entrectinib Capsule Compared to Nasogastric and Oral Administration of Suspension in Healthy Subjects
A phase I, single-dose, randomized, crossover, relative bioavailability and food-effect study and phase I, single-dose, fixed-sequence, crossover, pH-effect study of belvarafenib (GDC-5573) in healthy subjects
A Multiple-Center, Open-Label, Non-Randomized Study to Investigate The Effect of Various Degrees of Hepatic Impairment on The Pharmacokinetics of A Single Intravenous Dose of RO7223280
A study to look at how safe different doses of a new study medicine (RO7303509) were for healthy people to take – and how this medicine was processed through the body
Kidney Disorder
Chronic Kidney Disease
Ascertain the Optimal Starting Dose of Mircera Given Subcutaneously for Maintenance Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease on Dialysis or Not Yet on Dialysis.
A comparison of MIRCERA with reference erythropoiesis-stimulating agents (ESAs) for the treatment of anemia in chronic kidney disease (MIRCERA)
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of BFKB8488A Compared With Placebo in Participants With Non-Alcoholic Steatohepatitis
Renal Failure
A Study to Investigate the Effect of Renal Function and Hemodialysis on the Pharmacokinetics (PK) of RO7079901
A Study of Obinutuzumab to Evaluate Safety and Tolerability in Hypersensitized Adult Participants With End Stage Renal Disease Awaiting Transplantation
Childhood Nephrotic Syndrome
A clinical trial to compare obinutuzumab with mycophenolate mofetil (MMF) in children and young adults with a kidney disorder called idiopathic nephrotic syndrome
IGA Nephropathy
A clinical trial to see how well RO7434656 works compared with placebo in people with primary IgA nephropathy who are at high risk of their kidney disease getting worse
Metabolic Disorder
Type 1 Diabetes Mellitus
Participant-Reported Outcomes With the Accu-Chek® Solo Micropump System
A French Study to Evaluate the Usefulness of Implantable Continuous Glucose Monitoring (CGM) Sensor to Improve Glycemic Control in Participants With Diabetes Mellitus.
Accu-Chek® CONNECT at School (CATS) Pediatric Study
ACCU-CHEK Connect Personal Diabetes Management Study (PDM CONNECT)
Type 2 Diabetes Mellitus
A study to see how well the body tolerates different dose levels of a new medicine for type 2 diabetes mellitus and non-alcoholic fatty liver disease called “BFKB8488A”.
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of UTTR1147A in Participants With Neuropathic Non-Healing Diabetic Foot Ulcers
Liver Failure
A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants
Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib
Hepatic Insufficiency
What happens to a medicine (entrectinib) when given to people with unhealthy livers
A study to evaluate the processing by the body and safety of pralsetinib in participants with hepatic impairment compared to healthy participants
A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function
Diabetic Retinopathy
A clinical trial to compare different doses of RG7774 with a placebo in people with moderate and severe stages of non-proliferative diabetic retinopathy (NPDR), an eye disease that develops due to diabetes.
A Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm
Lysosomal Storage Diseases
Cardiovascular Disorder
Acute Ischemic Stroke
Tenecteplase in Stroke Patients Between 4 and 24 Hours
Study to Evaluate The Safety and Efficacy of Balovaptan in Patients With Acute Ischemic Stroke at High Risk of Developing Malignant Brain Edema
A clinical trial to compare balovaptan with placebo in people who have had a large stroke within the last 12 hours and are at high risk of developing severe brain swelling
A Phase I, open-label, multi-center, pharmacokinetic, pharmacodynamic and safety study of tenecteplase in adult patients with acute ischemic stroke
Coronary artery disease
A Phase Ic Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics Following 4 Weeks of NLRP3 Inhibition With Selnoflast in Participants With Coronary Artery Disease
Is it safe for people to take a new medicine (GDC-2394) – and how is the medicine is processed by the body
Hematologic diseases
An Observational Study to Evaluate Physical Activity, Bleeding Incidence and Health Related Quality of Life, in Participants With Haemophilia A Without Inhibitors Receiving Standard of Care Treatment
Beta-Thalassemia
A Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent (NTD) Beta-Thalassemia
Myelodysplastic Syndrome
A Study of Epoetin Beta Treatment in Anemic Participants With Myelodysplastic Syndrome (MDS)
Hemophilia
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Emicizumab Given Every 4 Weeks in Participants With Hemophilia A (HAVEN4)
A Study of Emicizumab Administered Subcutaneously (SC) in Pediatric Participants With Hemophilia A and Factor VIII (FVIII) Inhibitors (HAVEN2)
A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors (HAVEN3)
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants With Inhibitors (HAVEN1)
A clinical trial to look at how safe emicizumab is in patients with mild or moderate hemophilia A, and how emicizumab affects bleeding in this patient population.
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors
Hemophilia A
A clinical trial to investigate the impact of treatment with emicizumab on overall health, physical activity, and joint health in people with moderate or severe haemophilia A
A Study to Evaluate the Safety and Tolerability of Prophylactic Emicizumab in Hemophilia A Patients With Inhibitors (STASEY)
Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participants (HAVEN5)
Blood Disorder
Sickle Cell Disease
A clinical trial to evaluate the safety and effectiveness of crovalimab in reducing pain crises, also called vaso-occlusive episodes (VOE), in people with sickle cell disease (SCD)
A phase Ib randomized, placebo-controlled study evaluating the safety, pharmacokinetics, pharmacodynamics, and efficacy of crovalimab for the management of acute uncomplicated vaso-occlusive episodes in patients with sickle cell disease
Atypical Hemolytic Uremic Syndrome (aHUS)
A clinical trial to look at how safe and effective crovalimab is in children and adolescents with atypical haemolytic uraemic syndrome (aHUS)
A clinical trial to look at how well crovalimab works in adults and adolescents with atypical hemolytic uremic syndrome (aHUS)
Bone Marrow Transplant Disease
A Phase I, Open-label, Randomized, Dose-finding, Multicenter Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of GDC-8264 in Combination With Standard of Care in the Treatment of Acute Graft-versus-host Disease in Patients who have Undergone Allogeneic Hematopoietic Stem Cell Transplantation
Immunology
Acute Graft Versus Host Disease
A Study to Assess the Safety and Pharmacokinetics of GDC-8264 in Combination With Standard of Care in Participants With Acute Graft-Versus-Host Disease (aGVHD)
Neurology
A Study to Characterize Access to Specialty Care Received by American Indians/Alaska Natives
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