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ForPatients - Global
Trials
Cancer
A Study Evaluating Single-agent Inavolisib and Inavolisib Plus Atezolizumab in PIK3CA-Mutated Cancers
A study to evaluate the safety, tolerability, processing by the body, and antitumor activity of inavolisib and paclitaxel
Chronic Lymphocytic Leukaemia (CLL)
A study of the safety of a new medicine (DCLL9718S) in patients with a type of blood cancer (acute myeloid leukemia)
A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
A clinical trial to look at how safe different doses of mosunetuzumab are to give with or without atezolizumab in people with B-cell non-Hodgkin’s lymphoma or chronic lymphocytic leukaemia, how well they work, and how the body responds to and gets rid of the drugs
A clinical study to compare obinutuzumab in combination with venetoclax and obinutuzumab in combination with chlorambucil in people with previously untreated chronic lymphocytic leukaemia who have other medical conditions
A study to look at the safety and efficacy of obinutuzumab with bendamustine in people with a type of blood cancer called ‘chronic lymphocytic leukemia’ (GIBB)
A clinical trial to compare venetoclax plus obinutuzumab with fludarabine, cyclophosphamide and rituximab or bendamustine and rituximab in people with chronic lymphocytic leukemia.
A study to look at the side effects of a study medicine (efmarodocokin alfa) in patients undergoing hematopoietic stem cell transplantation (HSCT)
A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.
A clinical trial to compare how safe and effective different doses of mosunetuzumab on its own or in combination with other treatments are in people with chronic lymphocytic leukemia that has not responded to, or has come back after previous treatments
A Study to Evaluate the Benefit of Venetoclax Plus Rituximab Compared With Bendamustine Plus Rituximab in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
A study to look at the effects of Venetoclax in patients with Chronic Lymphocytic Leukemia who are on stable cBTKi therapy
Ovarian Cancer
A clinical trial comparing atezolizumab with a placebo when given with chemotherapy (paclitaxel and carboplatin) and bevacizumab in people newly diagnosed with advanced ovarian, fallopian tube or peritoneal cancer.
An Observational Study of Avastin (Bevacizumab) in Patients With Advanced/Metastatic Epithelial Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer
A Study of the Efficacy and Safety of Bevacizumab in Chinese Women With Newly Diagnosed, Previously Untreated Stage III or Stage IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
A clinical trial to look at how well cobimetinib works in combination with another drug called niraparib to slow, stop or reverse the course of ovarian cancer, and whether it works better when it is given with or without another drug called atezolizumab.
A Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With Rucaparib in Participants With Advanced Breast, Ovarian Cancer, and Prostate Cancer.
A clinical trial to look at the effects of different treatments on rare types of previously treated epithelial ovarian, fallopian tube or primary peritoneal cancers with different molecular changes
Colorectal Cancer
Study of Cobimetinib in Combination With Atezolizumab and Bevacizumab in Participants With Gastrointestinal and Other Tumors
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Metastatic Colorectal Cancer (Morpheus-CRC)
A clinical trial to look at how well cibisatamab works in combination with another drug called atezolizumab after pre-treatment with obinutuzumab to treat advanced colorectal cancer (CRC) after chemotherapy has not worked
A Study of BLYG8824A in Participants With Locally Advanced or Metastatic Colorectal Cancer
Study To Evaluate Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Anti-Tumor Activity Of RO7122290 In Combination With Cibisatamab With Obinutuzumab Pre-Treatment
A study to look at how well different targeted therapies work to treat colorectal cancer that has spread to other parts of the body
Cervical Cancer
A clinical trial to evaluate tiragolumab plus atezolizumab and atezolizumab on its own in people with cervical cancer (SKYSCRAPER-04)
Polycythemia Vera
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Idasanutlin Monotherapy in Participants With Hydroxyurea-Resistant/Intolerant Polycythemia Vera
A Study in Participants Previously Enrolled in a Genentech− and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
Bladder Cancer
Safety and Pharmacology Study of Atezolizumab Alone and in Combination With Bacille Calmette-Guérin (BCG) in High-Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) Participants
A Study of Atezolizumab Versus Observation as Adjuvant Therapy in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (UC) After Surgical Resection
Study of Atezolizumab as Monotherapy and in Combination With Platinum-Based Chemotherapy in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma
A clinical trial to look at how well atezolizumab works when taken with other drugs, compared to atezolizumab alone, in people with bladder cancer
A clinical trial to compare the effectiveness and safety of atezolizumab with placebo in people with bladder cancer
A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced or Metastatic Urothelial Cancer
A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (MIUC)
A Study of Eciskafusp Alfa and Bacillus Calmette-Guérin (BCG) in Participants with BGC-Unresponsive High-Risk Bladder Cancer
Lung Cancer
A study to compare divarasib with sotorasib or adagrasib in people with KRAS G12C-positive non-small cell lung cancer that has previously been treated and has either spread or has no other treatments available for it
A study to look at how safe and how well different targeted therapies work in people with non-small cell lung cancer that has certain biomarkers
A Study of Atezolizumab as Neoadjuvant and Adjuvant Therapy in Resectable Non-Small Cell Lung Cancer (NSCLC) - Lung Cancer Mutation Consortium (LCMC3)
A Study of Atezolizumab Compared With Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Containing Therapy
A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132)
A Study of MTIG7192A in Combination With Atezolizumab in Chemotherapy-Naïve Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
A clinical trial to understand the effect of targeted therapies for patients with non-­small cell lung cancer with different mutations (BFAST: Blood First Assay Screening Trial)
A clinical trial to compare atezolizumab with best supportive care after surgery and chemotherapy in people with non-small cell lung cancer
A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)
A study to compare alectinib with chemotherapy in people with ALK-positive non-small cell lung cancer after surgery (ALINA)
Alectinib compared with chemotherapy in previously treated patients with ALK-positive NSCLC (ALUR)
A study evaluating the efficacy and safety of neoadjuvant treatment with atezolizumab or placebo in combination with platinum-based chemotherapy in patients with resectable stage II, IIIA, or select IIIB non-small cell lung cancer
A Study of Carboplatin Plus Etoposide With or Without Atezolizumab in Participants With Untreated Extensive-Stage (ES) Small Cell Lung Cancer (SCLC)
A clinical trial to compare atezolizumab given as an injection under the skin, with atezolizumab given as an infusion into the vein, in people with lung cancer who have previously received treatment with chemotherapy
A Study to Evaluate and Compare the Efficacy and Safety of Alectinib Versus Crizotinib and to Evaluate the Pharmacokinetics of Alectinib in Asian Participants With Treatment-Naive Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC)
A Study of Atezolizumab Compared With Docetaxel in Non-Small Cell Lung Cancer (NSCLC) After Failure With Platinum-Containing Chemotherapy
A Study to Investigate the Safety and Efficacy of Atezolizumab in Previously-Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Prospective Clinicogenomic Program
A Study of Bevacizumab, Carboplatin, and Paclitaxel or Pemetrexed With or Without Atezolizumab in Chemotherapy-Naïve Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer (IMpower151)
A clinical trial to compare atezolizumab plus chemotherapy with or without tiragolumab in people with extensive stage small cell lung cancer
A Study of the Efficacy and Safety of RO7198457 in Combination With Atezolizumab Versus Atezolizumab Alone Following Adjuvant Platinum-Doublet Chemotherapy in Participants Who Are ctDNA Positive After Surgical Resection of Stage II-III Non-Small Cell Lung Cancer
A clinical trial to compare tiragolumab plus atezolizumab with placebo plus atezolizumab in people with untreated advanced non-small cell lung cancer
A Study of Alectinib, Entrectinib, or Vemurafenib Plus Cobimetinib in Participants With Stages I-III Non-Small Cell Lung Cancer With ALK, ROS1, NTRK, or BRAF v600E Molecular Alterations
A Study of Atezolizumab in Combination With Carboplatin Plus Etoposide to Investigate Safety and Efficacy in Patients With Untreated Extensive-Stage Small Cell Lung Cancer
Atezolizumab Consolidation in Limited Stage Small Cell Lung Cancer
A Study Comparing Alectinib With Crizotinib in Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer Participants
A Study of Atezolizumab in Combination With Bevacizumab in Patients With EGFR Mutation Positive Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
A clinical trial to compare atezolizumab and cabozantinib with docetaxel in people with metastatic non-small cell lung cancer (after previous treatment with a checkpoint inhibitor and platinum-containing chemotherapy has not worked).
A clinical trial to compare atezolizumab plus tiragolumab with durvalumab in people with Stage III non-small cell lung cancer that cannot be removed by surgery (unresectable) and whose cancer has not gotten worse after chemoradiotherapy (SKYSCRAPER-03)
A Study of Atezolizumab in Combination With Carboplatin + Paclitaxel or Carboplatin + Nab-Paclitaxel Compared With Carboplatin + Nab-Paclitaxel in Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower131]
A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases
A clinical trial to test platinum-doublet chemotherapy with or without atezolizumab in people with non-small cell lung cancer (NSCLC) who have had surgery
A study of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin versus pembrolizumab plus pemetrexed and carboplatin/cisplatin in patients with previously untreated advanced non-squamous non-small cell lung cancer
Study of Low-Dose Radiotherapy (LDRT) Concurrent Cisplatin/Carboplatin Plus Etoposide With Atezolizumab for Patients With Extensive-Stage Small Cell Lung Cancer
Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Participants With Untreated Extensive-Stage Small Cell Lung Cancer (SKYSCRAPER-02C)
A Study of Atezolizumab in Participants With Programmed Death - Ligand 1 (PD-L1) Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
A Study of Atezolizumab Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum-Containing Therapy
A Study of Atezolizumab in Combination With Carboplatin Plus (+) Paclitaxel With or Without Bevacizumab Compared With Carboplatin+Paclitaxel+Bevacizumab in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A Study of Atezolizumab in Combination With Carboplatin Plus (+) Nab-Paclitaxel Compared With Carboplatin+Nab-Paclitaxel in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A study evaluating the safety and efficacy of neoadjuvant and adjuvant tiragolumab plus atezolizumab, with or without platinum-based chemotherapy, in participants with previously untreated locally advanced resectable stage II, IIIA, or select IIIB non-small cell lung cancer
A clinical trial to compare a medicine called pralsetinib with standard-of-care chemotherapy treatments in people with non-small cell lung cancer (NSCLC)
A Study of Atezolizumab Compared With Platinum Doublet Chemotherapy for PD-L1 Highly Expressed, Chemotherapy-Naïve Patients With Stage IV Non-Squamous or Squamous Non-Small Cell Lung Cancer
A study of lurbinectedin in combination with atezolizumab compared with atezolizumab as maintenance therapy in participants with extensive-stage small-cell lung cancer (ES-SCLC) following first-line induction therapy with carboplatin, etoposide and atezolizumab
A study to find out if taking different forms of a medicine (GDC-6036) results in the same amount of medicine in your body – and the effect of food on the medicine
A clinical trial to look at how alectinib and entrectinib each work to reduce certain signs of cancer compared with durvalumab in people with advanced non-small cell lung cancer with specific abnormal genes, and how safe alectinib and entrectinib are
A Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer
A study to look at how well atezolizumab works in people with non-small cell lung cancer that has spread to nearby tissues, cannot be removed with surgery and has not worsened after radiotherapy and chemotherapy given together
A Phase II, single-arm study of tiragolumab plus atezolizumab and bevacizumab in patients with previously untreated locally advanced unresectable or metastatic PD-L1-positive non-squamous non-small cell lung cancer
A clinical trial to look at how safe and well RO7616789 works at different doses in people with small cell lung cancer (SCLC) that has spread or any neuroendocrine cancer (NEC), and how the body processes RO7616789
A clinical trial to compare RO7247669 plus platinum-based chemotherapy with pembrolizumab plus platinum-based chemotherapy in people with untreated non−small cell lung cancer that has grown or spread
Study of RO7515629 in Participants With HLA-G Positive Solid Tumors
A clinical trial to look at the safety and activity of divarasib at different doses in combination with other anti-cancer therapies in people with non-small cell lung cancer that have a KRAS G12C mutation and has spread, and who haven’t previously been treated for this.
A Study to Evaluate the Impact of Liquid Biopsy in Participants With a Clinical Diagnosis of Advanced Cancer
Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer
A clinical trial to compare tiragolumab plus atezolizumab versus placebo plus atezolizumab in people with non-small cell lung cancer
A Phase 1b Study of Atezolizumab in Combination With Erlotinib or Alectinib in Participants With Non-Small Cell Lung Cancer (NSCLC)
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Multiple Myeloma
A Study of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) Alone or in Combination With an Immunomodulatory Drug and/or Daratumumab in Participants With Multiple Myeloma (MM)
A Study of Cobimetinib Administered as Single Agent and in Combination With Venetoclax, With or Without Atezolizumab, in Participants With Relapsed and Refractory Multiple Myeloma
Dose-Escalation Study of BFCR4350A in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Preliminary Activity of Tiragolumab in Participants With Relapsed or Refractory Multiple Myeloma or With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
A study to find out if a new medicine (RO7297089) is safe and effective for people with cancer (multiple myeloma)
A clinical trial to look at how safe forimtamig is at different doses, how the body processes it, and how well it works against multiple myeloma that has come back after previous treatment
A study to look at the safety of cevostamab alone, and in combination with other treatments in people with relapsed or refractory multiple myeloma
A clinical trial to look at the safety and early activity of cevostamab when given subcutaneously at different doses in people with multiple myeloma after other treatments have not worked
A Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Participants With Relapsed/Refractory Multiple Myeloma
A clinical trial to look at how safe and well cevostamab works in people with multiple myeloma after other treatments have not worked
A PLATFORM STUDY EVALUATING THE SAFETY AND EFFICACY OF MULTIPLE TREATMENTS IN PATIENTS WITH MULTIPLE MYELOMA
A Dose-escalation Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma
A Study Evaluating the Safety, Pharmacokinetics, and Activity of the Combination of Cevostamab and Elranatamab in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)
A clinical trial to look at how safe forimtamig-based treatment combinations are and how well they work in people with relapsed or refractory multiple myeloma
A Study Evaluating the Pharmacokinetics, Safety, and Efficacy of Cevostamab in Chinese Participants With Relapsed or Refractory Multiple Myeloma
Renal Cell Cancer
A Clinical Trial of Atezolizumab in Patients with Renal Cell Carcinoma that is at High Risk of Coming Back After Surgery (IMmotion010)
A Study of Atezolizumab in Combination With Bevacizumab in Untreated Locally Advanced or Metastatic Clear Cell or Non-Clear Cell Renal Cell Carcinoma
A Study of Atezolizumab (Anti-PD-L1 Antibody) plus Bevacizumab versus Active Surveillance as Adjuvant Therapy in Patients with Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation
A clinical trial to compare atezolizumab plus cabozantinib with cabozantinib alone in people with kidney cancer after checkpoint inhibitor treatment has not worked.
A Study of Atezolizumab in Combination With Bevacizumab Versus Sunitinib in Participants With Untreated Advanced Renal Cell Carcinoma (RCC)
A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants with Previously Untreated Locally Advanced Unresectable or Renal Cell Carcinoma that has Spread from One Part of the Body to the Other
Melanoma
Cobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose Cancer Has Worsened During or After Treatment With Previous Immunotherapy and Atezolizumab Monotherapy in Participants With Previously Untreated Advanced Melanoma
A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Patients With Metastatic or Unresectable Locally Advanced Melanoma
A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous System Metastases
A Study to Evaluate The Efficacy And Safety Of RO7198457 In Combination With Pembrolizumab Versus Pembrolizumab Alone In Participants With Previously Untreated Advanced Melanoma.
Atezolizumab in Combination With Bevacizumab in Patients With Unresectable Locally Advanced or Metastatic Mucosal Melanoma
A clinical trial to look at how safe RO6874281 is in combination with another drug called pembrolizumab, and to look at how well the combination works to treat melanoma.
A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma
A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas
Hepatocellular Carcinoma
A Clinical Trial to Compare Atezolizumab plus Bevacizumab with Sorafenib in Patients with Untreated Advanced Hepatocellular Carcinoma (IMbrave150)
A Phase I Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases
A Study of Atezolizumab (Tecentriq) in Combination With Bevacizumab to Investigate Safety and Efficacy in Patients With Unresectable Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy-Amethista
A Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocellular Carcionma
A Study of Atezolizumab in Combination With Bevacizumab in Spanish Patients With Unresectable or Unsuitable for Locoregional Treatments Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy
A study to compare atezolizumab plus lenvatinib or sorafenib with lenvatinib or sorafenib alone in people with advanced and/or inoperable liver cancer (hepatocellular carcinoma) after previous treatment with atezolizumab plus bevacizumab
A clinical trial to look at how safe and effective different combinations of immunotherapy-based treatments are at reducing tumour size in people with advanced liver cancers
A clinical trial to compare tiragolumab plus atezolizumab and bevacizumab with placebo plus atezolizumab and bevacizumab in people with untreated, advanced hepatocellular carcinoma
A clinical trial to look at how safe and effective different combinations of treatment that include an immunotherapy are to reduce tumour size before surgery in people with liver cancer (hepatocellular carcinoma)
A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-Pugh B7 and B8 Cirrhosis
Study to Explore the Mechanism of Acquired Immune Escape In Participants With Metastatic Cancer Progressing on CPI Therapy
Head and Neck Cancer
A clinical trial to compare atezolizumab with a placebo in people with head and neck cancer who are at a high risk of their cancer returning or getting worse after completion of standard initial therapy.
A study of atezolizumab plus tiragolumab and atezolizumab plus placebo as first-line treatment in patients with recurrent/metastatic PD-L1 positive squamous cell carcinoma of the head and neck
A Study of RO7121661 and RO7247669 Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus
A Study to Evaluate the Efficacy and Safety of Multiple Treatment Combinations in Patients with Locally Advanced Squamous Cell Carcinoma of Head and Neck
A clinical trial to look at how well RO6874281 works in combination with another drug called atezolizumab to slow, stop or reverse the course of solid tumours
Brain Tumor
Study of RXDX-101 in Children With Recurrent or Refractory Solid Tumors and Primary CNS Tumors, With or Without TRK, ROS1, or ALK Fusions
Pancreatic Cancer
A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)
A study comparing the effects of an individualized drug product (autogene cevumeran) given in combination with an immunotherapy (atezolizumab) and chemotherapy (mFOLFIRINOX) compared to chemotherapy alone as post-surgery therapy in people with a type of cancer of the pancreas called pancreatic ductal adenocarcinoma (PDAC) after it has been surgically removed
My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors
A Study to Investigate the Efficacy and Safety of Cobimetinib Plus Atezolizumab in Participants With Solid Tumors
A Clinical Trial to Compare Targeted Therapy or Cancer Immunotherapy with Chemotherapy in Patients with Cancer of Unknown Primary (CUPISCO)
An Extension (Rollover) Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Malignancies Previously Enrolled in an Antecedent Vemurafenib Protocol
A Phase I Study of BTRC4017A in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers
A Roll Over Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During Transfection (RET)-Positive Cancer
Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Participants With Previously Treated Solid Tumors
Safety and Pharmacokinetics (PK) of Escalating Doses of MTIG7192A as a Single Agent and in Combination With Atezolizumab in Locally Advanced or Metastatic Tumors
Prostate Cancer
A Study of Atezolizumab (Anti-PD-L1 Antibody) in Combination With Enzalutamide in Participants With Metastatic Castration-Resistant Prostrate Cancer (mCRPC) After Failure of an Androgen Synthesis Inhibitor And Failure of, Ineligibility For, or Refusal of a Taxane Regimen
Ipatasertib Plus Abiraterone Plus Prednisone/Prednisolone, Relative to Placebo Plus Abiraterone Plus Prednisone/Prednisolone in Adult Male Patients With Metastatic Castrate-Resistant Prostate Cancer
Safety and Tolerability of Atezolizumab (ATZ) in Combination With Radium-223 Dichloride (R-223-D) in Metastatic Castrate-Resistant Prostate Cancer (CRPC) Progressed Following Treatment With an Androgen Pathway Inhibitor
Study of Ipatasertib or Apitolisib With Abiraterone Acetate Versus Coralie in Participants With Castration-Resistant Prostate Cancer Previously Treated With Docetaxel Chemotherapy
A clinical trial to compare the safety and effectiveness of ipatasertib plus atezolizumab and docetaxel in people with metastatic prostate cancer
A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer
A Study to Assess Pharmacokinetics and Safety of Atezolizumab Administered Intravenously (IV) as a Single Agent or in Combination With Chemotherapy to Chinese Participants With Locally Advanced or Metastatic Solid Tumors
An Extension Study of trastuzumab emtansine administered as a single agent or in combination with other anti-cancer therapies in patients previously enrolled in a Genentech and /or F. Hoffmann-La Roche Ltd. – sponsored trastuzumab emtansine study
Gastric Cancer
A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) (Morpheus-Gastric Cancer)
A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive Locally Advanced Resectable Gastric Cancer of Adenocarcinoma of Gastroesophageal Junction
A Study to Explore the Efficacy and Safety of Atezolizumab Plus Tiragolumab and Chemotherapy in 1st Line HER2 Negative Unresectable, Recurrent or Metastatic Gastric Cancer or Adenocarcinoma of Gastroesophageal Junction (GEJ)
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-Care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
A Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract
An Extension Study to Provide Continued Bevacizumab Therapy to Participants With Solid Tumors Who Were Previously Enrolled in a Roche/Genentech Sponsored Study
CUP
Non-Hodgkin's Lymphoma
A Study of Atezolizumab in Combination With Either Obinutuzumab Plus Bendamustine or Obinutuzumab Plus (+) Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Participants With Follicular Lymphoma (FL) or Rituximab + CHOP in Participants With Diffuse Large B-Cell Lymphoma (DLBCL)
A clinical trial to look at how safe, and how well mosunetuzumab alone or in combination with polatuzumab vedotin works in people with diffuse large B-cell lymphoma
A Study Evaluating the Safety and Efficacy of Atezolizumab in Combination With Obinutuzumab Plus Lenalidomide in Patients With Relapsed or Refractory Follicular Lymphoma
A Clinical Trial to Investigate the Effect of a Short Duration Infusion of Obinutuzumab in Patients with Previously Untreated Advanced Follicular Lymphoma (MO40597 study)
A clinical trial to compare how well treatment with polatuzumab vedotin plus rituximab plus gemcitabine plus oxaliplatin (Pola-R-GemOx) works in people with diffuse large B-cell lymphoma versus treatment with R-GemOx alone
A Study to Evaluate the Efficacy and Safety of Polatuzumab Vedotin in Combination With Bendamustine and Rituximab Compared With Bendamustine and Rituximab Alone in Chinese Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL).
A clinical trial to look at the safety and effectiveness of mosunetuzumab plus lenalidomide for treating follicular lymphoma
A study to look at whether longer rituximab treatment provides additional benefit in patients with non-Hodgkin lymphoma and whether this affects treatment safety (the MabCute study)
A clinical trial to look at whether RO7227166 combined with another treatment (either obinutuzumab or glofitamab) is safe and effective at different doses for patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma
A Study Evaluating the Safety and Efficacy of RO7082859 or Mosunetuzumab (RO7030816) in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma and High-Grade Large B-Cell Lymphoma
An Open-Label Phase lB/II Study of Glofitamab and Atezolizumab or Polatuzumab Vedotin in Adult Patients With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
A clinical study for people with B-cell non-Hodgkin lymphoma that looks at how safe and how well mosunetuzumab works when given in combination with polatuzumab vedotin
A Study of RO7082859 in Combination With Rituximab or Obinutuzumab Plus Chemotherapy in Participants With Non-Hodgkin Lymphomas
A Study of Obinutuzumab, Rituximab, Polatuzumab Vedotin, and Venetoclax in Relapsed or Refractory Follicular Lymphoma (FL) or Diffuse Large B-Cell Lymphoma (DLBCL)
A Study of Obinutuzumab, Polatuzumab Vedotin, and Lenalidomide in Relapsed or Refractory Follicular Lymphoma (FL) and Rituximab in Combination With Polatuzumab Vedotin and Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma
A Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Participants With B-Cell Non-Hodgkin Lymphoma
A Dose Escalation Study of RO7082859 as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
A study to look at how safe different doses of the study medicine - DCDS0780A - were for patients with non-Hodgkin’s Lymphoma that involved B cells
A study to compare glofitamab plus chemotherapy with rituximab plus chemotherapy in people with diffuse large B-cell lymphoma (after previous treatment has not worked)
A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax Combined With Chemotherapy in Participants With B-Cell Non-Hodgkin's Lymphoma (NHL) and DLBCL
A Study to Evaluate Glofitamab as Single Agent Administered After Pretreatment With Obinutuzumab in Chinese Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
A Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versus Intravenous (IV) Rituximab, in Combination With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, Prednisone) in Previously Untreated Participants With CD20 Positive Diffuse Large B-Cell Lymphoma (DLBCL)
A study to evaluate efficacy and safety of mosunetuzumab in combination with lenalidomide in comparison to rituximab in combination with lenalidomide in patients with follicular lymphoma
A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax in Combination With Polatuzumab Vedotin Plus Rituximab (R) and Cyclophosphamide, Doxorubicin, Prednisone (CHP) in Participants With Untreated BCL-2 Immunohistochemistry (IHC)-Positive Diffuse Large B-Cell Lymphoma (DLBCL)
A clinical trial to look at how well glofitamab plus R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone) worked in people with ctDNA high-risk diffuse large B-cell lymphoma (DLBCL)
A study to evaluate the safety, tolerability, processing by the body, mechanism of action, and effectiveness of glofitamab following obinutuzumab pretreatment in patients with B-cell non-Hodgkin lymphoma
A Study Evaluating the Effects of the Body on and the Safety and Effectiveness of Mosunetuzumab in Patients with Relapsed or Refractory Follicular Lymphoma.
A clinical trial to compare mosunetuzumab plus polatuzumab vedotin with rituximab plus gemcitabine plus oxaliplatin in people with relapsed or refractory aggressive non-Hodgkin’s lymphoma
A clinical trial to test CC-220 or CC-99282 in combination with mosunetuzumab, and CC-99282 in combination with glofitamab, in people with B-cell non-Hodgkin lymphoma.
A clinical trial to look at how well RO7443904 and glofitamab work (when taken together) to treat people with relapsed or refractory Non-Hodgkin’s lymphoma, and how safe the combination is.
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab Monotherapy in Participants With Select B-Cell Malignancies
A clinical trial to look at how safe and effective mosunetuzumab plus tiragolumab, with or without atezolizumab, is for the treatment of relapsed or refractory B-cell non-Hodgkin lymphoma (NHL)
A clinical trial to examine the effectiveness and safety of glofitamab in combination with R-ICE (rituximab plus ifosfamide, carboplatin and etoposide) in people with relapsed or refractory (treatment-resistant) diffuse large B-cell lymphoma
A study to look at how safe was it to give people with blood cancer (non-Hodgkin’s lymphoma and chronic lymphocytic leukemia) – different doses of a study medicine (fenebrutinib)
A clinical trial to look at how well glofitamab works on its own, and in combination with standard cancer chemotherapy plus immunotherapy in children and young adults with B-cell non-Hodgkin lymphoma (B-NHL) after one or multiple standard therapies have not worked
A clinical trial to compare glofitamab plus Pola-R-CHP with Pola-R-CHP alone in people with untreated large B-cell lymphoma
A clinical trial to compare how well glofitamab on its own works versus standard treatment in people with mantle cell lymphoma that has come back after or has not responded to treatment
A Study Evaluating the Safety and Efficacy of Glofitamab + Gemcitabine + Oxaliplatin in U.S. Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
A study to understand the optimization of the cytokine release syndrome profile for glofitamab along with gemcitabine plus oxaliplatin in patients with relapsed/refractory diffuse large B-cell lymphoma
A Study of the Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors
A clinical trial to continue to provide treatments to participants who benefitted from them in an atezolizumab-based trial sponsored by Genentech Inc. and/or F. Hoffmann-La Roche Ltd
A Dose Escalation and Expansion Study of RO7121661, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumors
Endometrial Cancer
A clinical trial to look at how well giredestrant works in people with Stage 1, Grade 1 endometrial cancer, how safe giredestrant is and to understand the way the body processes giredestrant
A clinical trial to find a safe and suitable dose of idasanutlin, and to see how well idasanutlin works when given with chemotherapy or venetoclax, in children and young adults with leukemia or solid tumours
A clinical trial to look at how safe and how well different doses of RO7247669 work in people with solid tumours that have grown or spread, and how the body processes RO7247669
Solid Tumors
An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Preliminary Efficacy of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) in Pediatric and Young Adult Participants With Solid Tumors
A clinical trial to look at how safe RO7284755 is at different doses and how well it works alone or together with atezolizumab to reduce solid tumours
A Study to Evaluate the Safety and Tolerability of RO7296682 in Participants With Advanced Solid Tumors.
A study of to find out if a new medicine (ipatasertib) behaves differently in people from China
A study of a medicine (GDC-0919) combined with another medicine (atezolizumab) in patients with cancer that has grown or spread
A study to look at how safe different doses of MOXR0916 were for patients with cancer – when combined with one or two other medicines
A Study of RO6958688 in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen Positive Solid Tumors
A clinical trial to understand how genetic testing can help doctors to decide which treatment is best for patients with solid tumours (TAPISTRY)
A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response
A Study to Evaluate the Safety and Tolerability of RO7296682 in Combination With Atezolizumab in Participants With Advanced Solid Tumors.
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
A clinical trial to look at how safe alectinib is, how the body processes it and how well it works in children and young people that have a solid tumour in the brain, body or spine that has a change in the ALK gene and did not respond to previous treatment or has no treatment options available
A Study to Evaluate Safety, Pharmacokinetics and Anti-Tumor Activity of RO7300490, as Single Agent or in Combination With Atezolizumab in Participants With Advanced Solid Tumors
A study to look at how safe different doses of atezolizumab were for patients – and how this medicine was processed through the body
Investigating side effects of a new medicine (migoprotafib) and whether it can be tolerated by people
A study to look at how safe different doses of the study medicine (MOXR0916) were for patients with solid tumor cancer that had spread and did not respond to previous treatment(s), and how this medicine was processed by the body
A Study to Assess the Safety and Tolerability of Atezolizumab in Combination With Other Immune-Modulating Therapies in Participants With Locally Advanced or Metastatic Solid Tumors
An Extension Study in Participants Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella C)
A Study to Evaluate Safety, Pharmacokinetics, and Preliminary Anti-tumor Activity of RO7444973 in Participants With Unresectable and/or Metastatic MAGE-A4-positive Solid Tumors
A study to evaluate safety, pharmacokinetics, and preliminary clinical activity of RO7276389 alone and in combination with cobimetinib in participants with BRAF-V600 mutation-positive advanced solid tumor or BRAF-V600 mutation-positive melanoma with central nervous system metastases
 A study to evaluate the use of a smartphone application and biosensor by cancer participants undergoing systemic treatments.
Screening Study for Participants With Malignant Tumors
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
A Phase I, Open-label, Non-randomized Study to Characterize the Impact of Dietary Modification on Inavolisib Associated Hyperglycemia and to Assess the CYP3A4 Induction Potential of Inavolisib using Midazolam as a Probe Substrate in Patients with Incurable Metastatic Solid Tumors Previously Treated with Multiple (≥2) Lines of Therapy
A study to evaluate the safety and pharmacokinetics of the intravenous fixed-dose combination (IV FDC) of tiragolumab and atezolizumab in participants with locally advanced, recurrent or metastatic solid tumors
A clinical trial to look at how safe and well RO7589831 works at different doses in people with advanced solid tumours, and how the body processes RO7589831
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
A Phase 1 Study of KSQ-4279 Alone and in Combination in Patients With Advanced Solid Tumors
A Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors with Resectable Disease with Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H)
A Study of RO7617991 in Patients With Locally Advanced or Metastatic MAGE-A4-Positive Solid Tumors
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7759065 as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Solid Tumors
A Dose-escalation Study of RO7567132 as Single Agent and in Combination With Atezolizumab in Participants With Advanced Solid Tumors
A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial
A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors
Thymic Carcinoma
A Study to Investigate the Efficacy and Safety of Atezolizumab (Tecentriq) in Previously-Treated Patients With Advanced Thymic Carcinoma
Glioma de alto grado
A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Adolescent Participants With High-Grade Glioma
Esophageal Squamous Cell Carcinoma
A clinical trial to evaluate the safety and effectiveness of atezolizumab with or without tiragolumab versus placebo in people with squamous cell esophageal cancer that cannot be surgically removed and has not got worse after prior chemoradiotherapy (SKYSCRAPER-07)
Cancer de l'oesophage
A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma
Melanoma
A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Atezolizumab in Patients With NRAS-mutant Advanced Melanoma.
A clinical trial to look at how well treatment combinations work in people with melanoma (Morpheus-Melanoma)
A clinical trial to compare the effectiveness and safety of different doses of RO7247669 in people with melanoma that cannot be removed by surgery or has spread to other organs
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
A clinical trial to compare bevacizumab and atezolizumab, cisplatin and gemcitabine with atezolizumab, cisplatin and gemcitabine in people with untreated biliary tract cancer
Thyroid Cancer
A clinical trial to compare pralsetinib with standard-of-care treatment (cabozantinib or vandetanib) in people with RET-mutated medullary thyroid cancer (RET-MTC)
Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Patients With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
Rectal Cancer
A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemotherapy in Participants With Locally Advanced Rectal Cancer
Glioblastoma
A clinical trial to look at how safe RO7428731 is at different doses, how the body processes it, and what effects RO7428731 has on the body in people with glioblastoma that has the marker EGFRvIII
Gastric and Gastroesophageal Junction Carcinoma
An Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Gastric or Gastroesophageal Junction Carcinoma
A study exploring the safety and efficacy of Atezolizumab in combination with Obinutuzumab or Rituximab anti-CD20 therapy in participants with Relapse/Refractory Marginal Zone Lymphoma (MZL), Mantle Cell Lymphoma (MCL) and Waldenström Macrobulinemia (WM)
How does the body process a cancer medicine (pralsetinib) – when it is taken together with another medicine (cyclosporine)
A clinical trial to see if a digital health solution, such as a digital patient monitoring solution, can help improve health outcomes in people who are being given anti-cancer treatment
A clinical trial to continue to provide cancer treatments to participants who benefitted from them in trials sponsored by Genentech Inc. and/or F. Hoffmann-La Roche Ltd
Tumor
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
Autoimmune Disorder
Giant Cell Arteritis
Juvenile Idiopathic Arthritis
A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)
A Study of Tocilizumab in Chinese Participants With Systemic Juvenile Idiopathic Arthritis (sJIA)
A Study of Subcutaneously (SC) Administered Tocilizumab (TCZ) in Participants With Polyarticular-Course Juvenile Idiopathic Arthritis (pJIA)
A Study of Subcutaneously Administered Tocilizumab in Participants With Systemic Juvenile Idiopathic Arthritis
Rheumatoid Arthritis
A study of long-term effects of fenebrutinib treatment in patients with rheumatoid arthritis
An Efficacy and Safety Study of Subcutaneous Tocilizumab in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Participants With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current Disease-Modifying Antirheumatic Drug (DMARD) Therapy
Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis Participants
Sjogren's Syndrome
Ulcerative Colitis
A Phase I Study of Etrolizumab Followed by Open-Label Extension and Safety Monitoring in Pediatric Patients With Moderate to Severe Ulcerative Colitis or Moderate to Severe Crohn's Disease
A study to look at a new medicine called “UTTR1147A” - how safe are different doses for healthy people and patients to take – and how is this medicine processed through the body
A Clinical Trial to Compare Etrolizumab with Infliximab in Patients with Moderate to Severe Ulcerative Colitis Who Have not Received Treatment with Tumour Necrosis Factor Inhibitors (Gardenia)
A Clinical Trial to Compare Etrolizumab with Placebo and Adalimumab in Patients with Moderate to Severe Ulcerative Colitis Who Have not Received Treatment with Tumour Necrosis Factor Inhibitors (Hibiscus I)
A Study of the Efficacy and Safety of Etrolizumab in Ulcerative Colitis Participants Who Have Been Previously Exposed to Tumor Necrosis Factor (TNF) Inhibitors
How does a new medicine (efmarodocokin alfa) compare to available medicine and placebo – in people with ulcerative colitis
Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies
A Study of the Efficacy and Safety of Etrolizumab Treatment in Maintenance of Disease Remission in Ulcerative Colitis (UC) Participants Who Are Naive to Tumor Necrosis Factor (TNF) Inhibitors
A study to look at the long-term safety of a medicine, efmarodocokin alfa, in people with ulcerative colitis
A Clinical Trial to Compare Etrolizumab with Placebo and Adalimumab in Patients with Moderate to Severe Ulcerative Colitis Who Have not Received Treatment with Tumour Necrosis Factor Inhibitors (Hibiscus II)
A study to evaluate the safety, tolerability, processing by the body and mechanism of action of RO7486967 in participants with ulcerative colitis
Crohn's Disease
A Clinical Trial of Etrolizumab for Patients with Moderately to Severely Active Crohn's Disease (Bergamot)
Open-Label Extension and Safety Study for Patients With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144
RO7790121 for the Treatment of Moderate to Severe Active Crohn's Disease
A study to assess the effectiveness and safety of induction therapy with RO7790121 in participants with moderately to severely active Crohn's disease
A study to test the effectiveness and safety of RO7790121 for induction and maintenance therapy in patients with moderately to severely active Crohn's disease
Systemic Lupus Erythematosus
A study to compare different doses of fenebrutinib with a “placebo” – in patients with lupus
A clinical trial to look at how well obinutuzumab works to reduce certain features of systemic lupus erythematosus (SLE) when compared to placebo
A clinical trial to compare different doses of mosunetuzumab in people with systemic lupus erythematosus (SLE)
A clinical trial to look at how safe different doses of RO7507062 are in people with systemic lupus erythematosus and how the body processes this drug
A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Pharmacodynamics, and Efficacy of P-CD19CD20-ALLO1 in Participants With Severe, Treatment-refractory Systemic Lupus Erythematosus (SLE)
A study of the long-term effects of fenebrutinib treatment in patients with lupus
A study to look at the effects of a new medicine (astegolimab) in comparison to placebo - in patients with eczema (atopic dermatitis)
Systemic Sclerosis
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of RO7303509 in Participants With Systemic Sclerosis
A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis
Inflammatory Bowel Disease (IBD)
An Observational Study to Assess the Relationship Between Disease Flare States and Patient-Reported Health Data, Health Data from a Wearable Activity Tracker, and Biomarker Data Obtained Through a Decentralized Process in Patients with Inflammatory Bowel Disease
A study to find out how safe is it to give people a new medicine called “GDC-8264” – including the effect of food on GDC-8264, and the effect of combining GDC-8264 with other medicines
A study to look at different doses and side effects of a new medicine - zinpentraxin alfa - in healthy people
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vixarelimab in Participants With Moderate to Severe Ulcerative Colitis (UC)
A Study to Evaluate the Efficacy and Safety of PF-06480605 in Adults With Moderate to Severe Ulcerative Colitis
A study to assess the effectiveness and safety of RO7790121 for induction and maintenance therapy in participants with moderately to severely active ulcerative colitis
A study to assess the effectiveness and safety of RO7790121 for induction therapy in participants with moderately to severely active ulcerative colitis
A Study to Evaluate the Activity, and Safety of Vixarelimab in Participants With Moderate to Severe Active Ulcerative Colitis
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Granulomatosis With Polyangiitis
A Phase IIa Study of Intravenous Rituximab in Pediatric Participants With Severe Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis
A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV)
Lupus Nephritis
A clinical trial to look at how well obinutuzumab works in treating people with lupus nephritis and how safe it is (REGENCY)
A Study to Evaluate the Safety and Efficacy of Obinutuzumab Compared With Placebo in Participants With Lupus Nephritis (LN)
A clinical trial to look at how well obinutuzumab works, how safe it is and how the body processes obinutuzumab in young people with lupus nephritis compared with placebo
A Phase I, multicenter, single-arm study to evaluate the pharmacokinetics, pharmacodynamics, and safety of crovalimab in patients with lupus nephritis
Neuromyelitis optica spectrum disorders
Efficacy and Safety Study of Satralizumab (SA237) as Monotherapy to Treat Participants With Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD)
Efficacy and Safety Study of Satralizumab (SA237) as Add-on Therapy to Treat Participants With Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD)
A clinical trial to look at the long-term safety and effects of satralizumab in people with neuromyelitis optica spectrum disorder.
A clinical trial to look at how the body processes satralizumab in children with neuromyelitis optica spectrum disorder (NMOSD)
A clinical trial to look at how effective and safe satralizumab is for treating people with neuromyelitis optica spectrum disorder (NMOSD)
Paroxysmal Nocturnal Hemoglobinuria
A clinical trial to compare how safe and effective crovalimab is in people with paroxysmal nocturnal hemoglobinuria (PNH) currently treated with complement inhibitors.
A clinical trial to compare how effective and safe crovalimab is in comparison to eculizumab in people with paroxysmal nocturnal hemoglobinuria (PNH) not previously treated with complement inhibitors.
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibition
Primary Membranous Nephropathy
A clinical trial to compare obinutuzumab with tacrolimus in people with a kidney disease called primary membranous nephropathy.
MOG Antibody Disease
A clinical trial to compare satralizumab with placebo, with or without background therapy, in people with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
Autoimmune Encephalitis
A clinical trial to compare satralizumab with placebo in people with autoimmune encephalitis
Guillain-Barré Syndrome
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Participants With Guillain-Barré Syndrome (GBS)
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps
An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
Multiple Sclerosis
Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Participants With Early Stage Relapsing Remitting Multiple Sclerosis (RRMS)
A clinical extension trial to look at how well and safe ocrelizumab works long-term in people with multiple sclerosis who benefitted from ocrelizumab in a previous F. Hoffmann-La Roche Ltd sponsored trial
A Study to Evaluate the Safety of Administering Ocrelizumab Per a Shorter Infusion Protocol in Participants With Primary Progressive Multiple Sclerosis (PPMS) and Relapsing Multiple Sclerosis (RMS).
A Clinical Trial of Ocrelizumab in Patients with Progressive Multiple Sclerosis (CONSONANCE)
Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)
A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
A Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administration In Patients With Multiple Sclerosis
A clinical trial to find a safe and suitable dose of ocrelizumab in children and adolescents with relapsing-remitting multiple sclerosis
A clinical trial to compare the safety and effectiveness of ocrelizumab with placebo in people with primary progressive multiple sclerosis (PPMS)
Prospective Study to Assess Disease Activity and Biomarkers in Minority Participants With Relapsing Multiple Sclerosis (RMS) After Initiation and During Treatment With Ocrelizumab
A Study to Evaluate the Effects of Ocrelizumab on Immune Responses In Participants With Relapsing Forms of Multiple Sclerosis
A study to evaluate the efficacy, safety and pharmacokinetics of a higher dose of ocrelizumab in adults with relapsing multiple sclerosis
A study to evaluate the efficacy and safety of fenebrutinib compared with ocrelizumab in adult patients with primary progressive multiple sclerosis (FENtrepid)
A study to evaluate the efficacy, safety and pharmacokinetics of a higher dose of ocrelizumab in adults with primary progressive multiple sclerosis (PPMS)
A study to evaluate the efficacy and safety of fenebrutinib compared with teriflunomide in adult patients with relapsing multiple sclerosis (FENhance 1)
A study to evaluate the efficacy and safety of fenebrutinib compared with teriflunomide in adult patients with relapsing multiple sclerosis (FENhance 2)
A Study of Ocrelizumab in Participants With Primary Progressive Multiple Sclerosis
A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis
A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy
A Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumab
A study to investigate the efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta)
A clinical trial to compare the safety and effectiveness of ocrelizumab with fingolimod in children and young people with relapsing-remitting multiple sclerosis (RRMS)
A study to evaluate specific unmet needs in the current clinical practice of multiple sclerosis
A Study To Determine The Effect Of Ocrelizumab On Leptomeningeal Inflammation In Multiple Sclerosis
A clinical trial to examine if an injection of ocrelizumab under the skin is a safe and effective alternative way of treating patients with multiple sclerosis (MS)
A rollover study to evaluate the long-term safety and efficacy of ocrelizumab in patients with multiple sclerosis
A clinical trial to look at how safe different doses of RO7121932 are in people with multiple sclerosis and how the body processes RO7121932
A phase I, open-label, single-dose study to evaluate the effect of mild or moderate hepatic impairment on the pharmacokinetics of fenebrutinib
Testing different doses of a new medicine (fenebrutinib) and its effect on heart rhythm (QT interval) in healthy people
A phase I, open-label, single-dose study to evaluate the effect of severe renal impairment on the pharmacokinetics of fenebrutinib
An Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocrelizumab Treatment
A Study of the Efficacy and Safety of Ocrelizumab in Patients With Relapsing-Remitting Multiple Sclerosis
Atopic Dermatitis
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Atopic Dermatitis
Eye Disorder
Glaucoma
Age-Related Macular Degeneration
A study to look at how safe a study medicine was for patients – when taken at different doses - and how this medicine was processed through the body
A Clinical Trial to Test an Ocular Implant that Releases Ranibizumab Compared with Eye Injections of Ranibizumab in Patients with Wet Age-Related Macular Degeneration (Archway)
Study to Evaluate Faricimab (RO6867461; RG7716) for Extended Durability in the Treatment of Neovascular Age Related Macular Degeneration (STAIRWAY)
A clinical trial to look at how safe an eye implant that releases ranibizumab is for people with wet age-related macular degeneration when refilled every 6 or 9 months – and to find out the long-term effects of the eye implant and ranibizumab
Testing a new medicine (galegenimab) to find out if it is effective for a type of eye disease (geographic atrophy secondary to age-related macular degeneration)
Study of the Efficacy and Safety of the Ranibizumab Port Delivery System for Sustained Delivery of Ranibizumab in Patients With Subfoveal Neovascular Age-Related Macular Degeneration (LADDER)
Study of RO7250284 in Participants With Neovascular Age-Related Macular Degeneration
The long-term study of a new medicine (galegenimab) in people with a type of eye disease (geographic atrophy secondary to age-related macular degeneration)
The study of a new medicine (RO7303359) in people with a type of eye disease (geographic atrophy secondary to age-related macular degeneration)
A clinical trial to look at how an eye implant that continuously releases ranibizumab works to reduce certain signs of wet age-related macular degeneration, how safe the eye implant and ranibizumab are, and how the body gets rid of and responds to ranibizumab
A clinical trial to look at the long-term safety of faricimab in patients with neovascular age-related macular degeneration (nAMD, also known as wet AMD)
A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age‑Related Macular Degeneration (AMD) (AVENUE)
A clinical trial to evaluate maintenance of vision after switching to treatment with an eye implant containing ranibizumab in participants with neovascular age-related macular degeneration
A clinical trial in people with wet age-related macular degeneration (wet AMD) which compares (a) ranibizumab delivered by a permanent eye implant with (b) aflibercept delivered by injections into the eye
A study to evaluate the long-term safety and tolerability of faricimab administered in patients previously enrolled in Roche-sponsored studies
An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration
Wet Age-Related Macular Degeneration
A clinical trial to compare faricimab with aflibercept in people with neovascular age-related macular degeneration. (Tenaya)
A clinical trial to compare faricimab with aflibercept in people with neovascular age-related macular degeneration. (Lucerne)
A Study Conducted to Evaluate the Conjunctiva and Tenon's Capsule Status of Healthy Subjects and in Participants With Neovascular Age-related Macular Degeneration (nAMD)/Diabetic Macular Edema (DME)
A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD
Retinal Vein Occlusion
A clinical trial to compare the experimental treatment faricimab with the approved medicine aflibercept in people with macular oedema due to blockage of at least one branch of the retinal blood vessels within the eye
A clinical trial to compare faricimab with aflibercept in people with macular oedema due to blockage of the central (main) retinal vein or the hemiretinal vein (main branch of the smaller blood vessels) within the eye
Neovascular Age-related Macular Degeneration
A Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate the Safety of the Faricimab Prefilled Syringe
A Study of the Efficacy, Safety, and Pharmacokinetics (PK) of the Port Delivery System With Ranibizumab (PDS) in Chinese Participants With Neovascular Age-related Macular Degeneration (nAMD)
A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration
Polypoidal Choroidal Vasculopathy (PCV)
A Phase IIIb/IV, multicentre, open-label, single-arm study to investigate the efficacy and safety of faricimab (RO6867461) in patients with polypoidal choroidal vasculopathy
Dry Macular Degeneration
A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette)
A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
Uveitic Macular Edema
A clinical trial to look at how well RO7200220 works to improve vision compared with a sham treatment in people with inflammation-related fluid swelling in the eye (uveitic macular edema), and how safe RO7200220 is at different doses
A clinical trial to look at how well RO7200220 works to improve vision compared with a sham treatment in people with inflammation-related fluid swelling in the eye (uveitic macular edema), and how safe RO7200220 is at different doses
Myopia
A Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Choroidal Neovascularization Secondary to Pathologic Myopia
Thyroid Eye Disease
A clinical trial to compare satralizumab against placebo in people with thyroid eye disease
A clinical trial to compare satralizumab against placebo in people with thyroid eye disease
Muscle And Peripheral Nerve Disease
Duchenne Muscular Dystrophy
Clinical Trial to Evaluate the Efficacy, Safety, and Tolerability of RO7239361 in Ambulatory Boys With Duchenne Muscular Dystrophy
A Gene Transfer Therapy Study to Evaluate the Safety of SRP-9001 (Delandistrogene Moxeparvovec) in Participants With Duchenne Muscular Dystrophy (DMD)
A Gene Delivery Study to Evaluate the Safety and Expression of Delandistrogene Moxeparvovec in Participants Under the Age of Four With Duchenne Muscular Dystrophy (DMD)
A study to check the effect of satralizumab in children and adolescents living with Duchenne muscular dystrophy, to check if it is safe and also how it affects the different parts of the body and how it is eliminated from the body (SHIELD DMD)
Muscular Dystrophy
Study of an Investigational Drug, RO7239361 (BMS-986089), in Ambulatory Boys With DMD
Facioscapulohumeral Muscular Dystrophy (FSHD)
A clinical trial to compare RO7204239 with placebo in people with facioscapulohumeral muscular dystrophy
Infectious Diseases
Hepatitis B Virus
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7049389 in Healthy Volunteers and Chronic Hepatitis B Virus (HBV) Infected Participants
A Study in Healthy Volunteers and in Participants With Chronic Hepatitis B to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7020531
A Study of Pegylated Interferon Alfa-2A in Combination With Lamivudine or Entecavir Compared With Untreated Control Group in Children With Hepatitis B Envelope Antigen (HBeAg)-Positive Chronic Hepatitis B (CHB) in the Immune-Tolerant Phase
A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B
Influenza
Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants From Birth to < 1 Year With Influenza-Like Symptoms
Study to Assess Efficacy and Safety of Baloxavir Marboxil In Combination With Standard-of-Care Neuraminidase Inhibitor In Hospitalized Participants With Severe Influenza
A clinical trial to look at how well baloxavir reduces the spread of the flu within households, compared with a placebo (no active treatment).
A clinical trial to look at changes in flu virus before and after treatment with baloxavir marboxil in children – to understand more about treatment resistance
Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Chinese Pediatric Participants 1 to <12 Years of Age With Influenza Symptoms
Bacterial Infection
A study to look at how safe different doses of a new medicine called “DSTA4637S” were for patients – and how this medicine was processed through the body
A Study to Investigate the Pharmacokinetics of RO7223280 in Critically Ill Participants With Bacterial Infections
A multiple-center, non-randomized, open-label study to investigate the effect of various degrees of renal impairment on the pharmacokinetics of a single intravenous dose of RO7223280
A study to compare different doses of fenebrutinib with a “placebo” – in patients with an autoimmune disease called “chronic spontaneous urticaria”
A study of long-term effects of fenebrutinib treatment in patients with chronic spontaneous urticaria
Hepatitis C Virus
COVID-19 Pneumonia
A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia
A Study to Evaluate the Efficacy and Safety of Tocilizumab in Hospitalized Participants With COVID-19 Pneumonia
A study to find out if a new medicine (either astegolimab or efmarodocokin alfa) was safe and effective in patients with severe COVID-19 pneumonia
Study to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19
A clinical trial to compare the safety and effectiveness of AT-527 with placebo in people with mild or moderate COVID-19
A clinical trial to observe patients with a diagnosis of COVID-19, who have previously taken part in an AT-527 COVID-19 clinical trial
A clinical trial to look at the safety and activity of tocilizumab in children and adolescents with COVID-19
Chronic Hepatitis B
A clinical trial to look at the safety and effectiveness of RO7565020 at different doses and how the body processes RO7565020 in healthy people and those with hepatitis B
A phase I, randomized, double-blind, multiple-ascending-dose study to evaluate the safety and pharmacokinetics of GDC-5780 in healthy subjects
A sponsor-open, randomized, placebo-controlled, phase I study to investigate the pharmacokinetics, safety, and tolerability of RO7223280 in healthy Chinese participants following single IV dose administration
Chlamydia Trachomatis Infection
Mycosis
Systemic mycosis
Candidiasis
Performance Study of the Cobas® BV/CV Test on Samples From Participants With and Without Symptoms of Bacterial Vaginosis and Candida Vaginitis
Neurodegenerative Disorders
Alzheimer’s Disease Information
A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer’s Disease (AD)
A Study to Evaluate the Efficacy and Safety of RO7105705 in Patients With Prodromal to Mild Alzheimer's Disease
Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
CREAD Study: A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer’s Disease (AD)
A study of a new medicine (semorinemab) in patients with moderate Alzheimer's disease
A Study of Gantenerumab in Participants With Mild Alzheimer Disease
A Study of Gantenerumab in Participants With Prodromal Alzheimer's Disease
Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's Disease
A clinical trial to look at the long-term effects of gantenerumab in people with Alzheimer’s disease
A clinical trial to look at the safety and effects of long-term treatment with gantenerumab in people with Alzheimer's disease
A study comparing different tools for looking at the brain in people with Alzheimer’s disease: tau radiotracers for brain imaging with Positron Emission Tomography (PET)
A clinical trial to look at the effects of gantenerumab on the body in people with early Alzheimer’s disease
A study to state how safe RO7126209 is at different doses and how the body processes RO7126209
A Study of Crenezumab in Participants With Mild to Moderate Alzheimer Disease
A clinical trial to compare gantenerumab with placebo in people who are at risk for, or are in the earliest stages of, Alzheimer’s disease (AD)
A clinical trial to look at how well RO7269162 works in people who are at risk of Alzheimer’s disease or who have mild cognitive impairment due to Alzheimer’s disease and how safe RO7269162 is at different doses
A Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers to Evaluate Efficacy and Safety in the Treatment of Autosomal-Dominant Alzheimer's Disease (AD), Including a Placebo-Treated Non-Carrier Cohort
Amyotrophic Lateral Sclerosis
A study to look at a new medicine called, “GDC-0134”, for treating patients with amyotrophic lateral sclerosis (ALS)
Parkinson's Disease
A study to evaluate whether Prasinezumab can slow or halt disease progression in people with a recent diagnosis of Parkinson’s disease.
A study to evaluate the efficacy and safety of intravenous prasinezumab in participants with early Parkinson's disease
A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease.
Huntington's Disease
A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Patients With Manifest Huntington’s Disease
Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington’s Disease
BN40697 - A study to look at tominersen safety over 15 months in people with Huntington’s disease
An Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of RO7234292 (RG6042) in Patients With Huntington's Disease
A Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and Safety and Tolerability Following Intrathecal Administration in Patients With Huntington's Disease
A clinical trial to compare different doses of tominersen with a placebo in people with prodromal (very early subtle signs) and early manifest Huntington’s disease
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
Relapsing Multiple Sclerosis (RMS)
A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis
Neurodevelopmental Disorder
Autism Spectrum Disorder
A Clinical Trial of Balovaptan in Adults with Autism Spectrum Disorder (V1ADUCT)
A Study to Investigate the Efficacy and Safety of RO5285119 in Participants With Autism Spectrum Disorder (ASD)
The Effect of Hepatic Impairment on the Pharmacokinetics of Balovaptan
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants
Autism
A clinical trial to compare different doses of an investigational drug (called ‘RO7017773’) with a placebo (a pretend drug) in people with Autism Spectrum Disorder
Angelman Syndrome
A Study To Investigate The Safety Of RO7248824 in Children With Angelman Syndrome And To Understand The Way The Body Processes The Investigational Therapy
A Study To Assess Distribution Of RO7248824 In The Central Nervous System Following Single Intrathecal Doses Of [89zr] Labeled RO7248824 In Healthy Male Participants
A 12-week study to investigate how the body handles alogabat once it is swallowed, how safe it is, and whether it could be effective in treating the symptoms of AS
A study to investigate the effect of enzyme inhibition on the bodily processing of RO6953958 in healthy participants
Dup15q Syndrome
A clinical trial to compare the effects of basmisanil with a placebo in children with Dup15q syndrome
Psychiatric Disorder
Schizophrenia
A Study to Assess the Effects of RO6889450 in Participants With Schizophrenia or Schizoaffective Disorder and Negative Symptoms
A Trial of the Efficacy and the Safety of RO6889450 vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder
A study to evaluate the safety, tolerability, processing by the body and mechanism of action of multiple doses of ralmitaront with a single dose of risperidone administered to healthy participants
Post Traumatic Stress Disorder
Study To Evaluate The Efficacy And Safety Of Balovaptan In Adults With Post-Traumatic Stress Disorder (PTSD)
Post Traumatic Stress Disorder
Respiratory Disorder
Idiopathic Pulmonary Fibrosis
A Study to Characterize the Disease Behavior of Idiopathic Pulmonary Fibrosis (IPF) and Interstitial Lung Disease (ILD) During the Peri-Diagnostic Period
Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Risk of Group 3 Pulmonary Hypertension
A Study to Evaluate the Efficacy and Safety of PRM-151 in Patients With Idiopathic Pulmonary Fibrosis
A Study to Evaluate Long Term Safety and Efficacy of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis
A study to look at two generations of a medicine (zinpentraxin alfa) – that were manufactured in two different ways – how do they move through the body, from absorption to elimination
A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease
Asthma
A study to compare different doses of MSTT1041A with a “placebo” – in patients with severe asthma
A study to find out if a new medicine – MTPS9579A – works in people with asthma
A study to find out how safe is it to give people with asthma a new medicine called MTPS9579A
A clinical trial to compare the safety and effectiveness of selnoflast with a placebo and understand how the body processes selnoflast in people with moderate to severe asthma
A study of a new medicine for asthma and cough: GDC-6599, a TRPA1 inhibitor
Chronic Obstructive Pulmonary Disease
A Study Of ¹²⁹XE MRI To Assess Disease Progression In Patients With COPD Treated With Or Without Azithromycin And Standard-of-Care Medications
A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
A study to assess the safety of RO7486967 in patients with chronic obstructive pulmonary disease
A clinical trial to see how well different doses of astegolimab plus standard treatment work compared with a placebo plus standard treatment to reduce certain symptoms of chronic obstructive pulmonary disease
A clinical trial to look at how safe astegolimab is when given over a long period of time for people with chronic obstructive pulmonary disease by measuring the number and seriousness of side effects
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-Obstructive Disease
Unexplained Chronic Cough
A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamic Effects Of GDC-6599 In Patients With Chronic Cough
Healthy Volunteers
A study to look at how safe different doses of GDC-0334 were for healthy people and how this medicine was processed through the body
A clinical study to look at how safe crovalimab is at different doses and how well it works to reduce certain signs of paroxysmal nocturnal hemoglobinuria (PNH)
A study to find out if people get the same amount of medicine when they take the two different forms.
A study to find out if taking different forms of GDC-0134 gives you the same amount of medicine in your body
A study to find out if taking different forms of a medicine (GDC-9545) results in the same amount of medicine in your body – and the effect of food on the medicine
A Study To Investigate The Safety, Tolerability And Pharmacokinetics (PK) Of RO7223280 Following Intravenous Administration In Healthy Participants
A study to find out what happens to a new medicine inside women’s bodies – and to look at different forms of the medicine (giredestrant)
A study to investigate the processing by the body, safety, and side effects of gantenerumab in healthy Chinese participants following a single dose
A study to find out how safe is it to give people a new medicine for asthma (GDC-4379), and to see how this medicine is processed in the body
A study to look at how safe different doses of RO7497987 were for healthy people to take – and how this medicine was processed through the body
A study to find out if blood sampling techniques used in clinical trials can be replaced with better options
A study to find out if people get the same amount of medicine (alectinib) - when they take different forms of the medicine - with or without food.
A Phase I randomized, investigator/participant-blind, adaptive, single ascending dose, placebo-controlled study to investigate the safety, tolerability, pharmacokinetics, and food effects of RO7308480 following oral administration in healthy participants
A study to look at how safe different doses of a new medicine (GDC-5780) were
A Study in Healthy Male Subjects to Investigate the Comparability of Pharmacokinetics of the Fixed-Dose Combination of Pertuzumab and Trastuzumab Administered Subcutaneously Using a Handheld Syringe or Using the On-Body Delivery System
A non-randomized, open-label, single-dose study to investigate the intrapulmonary penetration of RO7223280 following intravenous administration in healthy participants
Open-label, non-randomized study investigating the excretion balance, pharmacokinetics, and metabolism of a single intravenous dose of [14C]-labelled RO7223280 in healthy male participants
A study in healthy volunteers to look at the side effects of a medicine (GDC-6988) – in comparison to a placebo – and the effects of salbutamol
What happens to a medicine (entrectinib) when given to people in different forms
A study to compare two different forms of a study medicine (belvarafenib), and look at the effect of food and stomach acid
A Multiple-Center, Open-Label, Non-Randomized Study to Investigate The Effect of Various Degrees of Hepatic Impairment on The Pharmacokinetics of A Single Intravenous Dose of RO7223280
A study to look at how safe different doses of a new study medicine (RO7303509) were for healthy people to take – and how this medicine was processed through the body
A study to find out what happens to a new medicine (divarasib) inside the human body
A single-center, open-label, adaptive, two-period, single oral dose, phase I study to assess the period effect (and the effect of food) on the pharmacokinetics of RO7268489 in healthy participants
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Obinutuzumab in Chinese Patients With ISN/RPS 2003 Class III or IV Lupus Nephritis
Evaluation of the Effects of Interval Between Lumbar Punctures on Cerebrospinal Fluid and Blood Analytes in Healthy Volunteers
A Phase 1, Open-label, Single-dose Study to Evaluate the Effect of Moderate or Severe Renal Impairment on the Pharmacokinetics of Inavolisib
A non-randomized, open-label, non-controlled, adaptive, multiple-dose study to investigate the safety, tolerability, and pharmacokinetics of zosurabalpin following intravenous administration in healthy participants
Healthy Male Subjects
A Study to Evaluate Single Subcutaneous Doses of NXT007 Among Injection Sites Abdomen, Upper Arm, and Thigh in Healthy Male Participants
A Phase I, randomized, double-blind, single ascending dose and multiple ascending dose study to evaluate the safety and pharmacokinetics of GDC-0829 in healthy subjects
A single-center, non-randomized, open-label, parallel group, adaptive, phase I positron emission tomography (PET) study to assess the brain occupancy following single oral doses of RO7268489 in healthy participants
A phase I, open-label, single-dose randomized, two-period crossover study to evaluate the relative bioavailability of single oral doses of two different formulations of divarasib (GDC-6036; 200-mg tablet and 400-mg tablet) in healthy subjects
A single-and multiple-dose, open-label, Phase I study to investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of subcutaneously administered RO7204239 in adult participants with high body weight
A Study to Evaluate the Effect of Injection Site on PK of Astegolimab in Healthy Subjects
A study medicine (fenebrutinib) manufactured in different ways – how do different fenebrutinib formulations move through the body
A Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Divarasib in Healthy Participants
A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants
A Study Investigating [14C]-Labeled RO7269162 in Healthy Male Participants
A Study Investigating the Effect of Different Approved Medications on How the Body Processes the Study Compound RO7795081
A Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Divarasib in Healthy Participants
Kidney Disorder
Chronic Kidney Disease
A study of a new medicine (fazpilodemab) in people with a type of liver disease called non-alcoholic steatohepatitis or NASH
Renal Failure
A Study of Obinutuzumab to Evaluate Safety and Tolerability in Hypersensitized Adult Participants With End Stage Renal Disease Awaiting Transplantation
Childhood Nephrotic Syndrome
A clinical trial to compare obinutuzumab with mycophenolate mofetil (MMF) in children and young adults with a kidney disorder called idiopathic nephrotic syndrome
IGA Nephropathy
A clinical trial to see how well RO7434656 (also called sefaxersen) works compared with placebo in people with primary IgA nephropathy who are at high risk of their kidney disease getting worse
Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)
Metabolic Disorder
Type 1 Diabetes Mellitus
A Study of CT-868 in Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
A study to see how well the body tolerates different dose levels of a new medicine for type 2 diabetes mellitus and non-alcoholic fatty liver disease called “BFKB8488A”.
Liver Failure
A Study to Evaluate the Pharmacokinetics of Divarasib in Healthy Participants and Participants With Impaired Hepatic Function
A study investigating the effect of various degrees of liver function impairment on the absorption and elimination of RO7434656, a new compound for the treatment of immunoglobulin A nephropathy
Hepatic Insufficiency
What happens to a medicine (entrectinib) when given to people with unhealthy livers
What happens to a medicine (pralsetinib) when given to people with unhealthy livers
Diabetic Retinopathy
A clinical trial to compare different doses of RG7774 with a placebo in people with moderate and severe stages of non-proliferative diabetic retinopathy (NPDR), an eye disease that develops due to diabetes.
A Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm
Lysosomal Storage Diseases
Obesity
A Study of CT-388 in Participants with Obesity or Overweight with At Least One Weight-Related Comorbidity
A study of CT-388 in participants living with obesity or overweight and Type 2 diabetes
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants
Metabolic dysfunction-associated steatohepatitis (MASH)
A Study to Assess the Safety, Pharmacokinetics, and Activity of RO7790121 in Participants With Advanced MASH Liver Fibrosis
Cardiovascular Disorder
Acute Ischemic Stroke
Tenecteplase in Stroke Patients Between 4 and 24 Hours
A clinical trial to compare balovaptan with placebo in people who have had a large stroke within the last 12 hours and are at high risk of developing severe brain swelling
A Phase I, open-label, multi-center, pharmacokinetic, pharmacodynamic and safety study of tenecteplase in adult patients with acute ischemic stroke
Coronary artery disease
A Phase Ic Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics Following 4 Weeks of NLRP3 Inhibition With Selnoflast in Participants With Coronary Artery Disease
Is it safe for people to take a new medicine (GDC-2394) – and how is the medicine is processed by the body
Myocardial Infarction
Hematologic diseases
Beta-Thalassemia
Myelodysplastic Syndrome
Hemophilia
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Emicizumab Given Every 4 Weeks in Participants With Hemophilia A (HAVEN4)
A Study of Emicizumab Administered Subcutaneously (SC) in Pediatric Participants With Hemophilia A and Factor VIII (FVIII) Inhibitors (HAVEN2)
A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors (HAVEN3)
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants With Inhibitors (HAVEN1)
A study to look at how well emicizumab works when given every 1, 2, or 4 weeks to prevent bleeds in people with mild or moderate haemophilia A without factor 8 inhibitors
A study to look at how safe emicizumab treatment is and how well it works to prevent bleeds in children with haemophilia A (without factor 8 inhibitors) who started emicizumab in their first year of life
Hemophilia A
A clinical trial to investigate the impact of treatment with emicizumab on overall health, physical activity, and joint health in people with moderate or severe haemophilia A
A Study to Evaluate the Safety and Tolerability of Prophylactic Emicizumab in Hemophilia A Patients With Inhibitors (STASEY)
Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participants (HAVEN5)
Blood Disorder
Sickle Cell Disease
A clinical trial to evaluate the safety and effectiveness of crovalimab in reducing pain crises, also called vaso-occlusive episodes (VOE), in people with sickle cell disease (SCD)
A phase Ib randomized, placebo-controlled study evaluating the safety, pharmacokinetics, pharmacodynamics, and efficacy of crovalimab for the management of acute uncomplicated vaso-occlusive episodes in patients with sickle cell disease
Atypical Hemolytic Uremic Syndrome (aHUS)
A clinical trial to look at how safe and effective crovalimab is in children and adolescents with atypical haemolytic uraemic syndrome (aHUS)
A clinical trial to look at how well crovalimab works in adults and adolescents with atypical hemolytic uremic syndrome (aHUS)
Blood platelet disorder
Bone Marrow Transplant Disease
Immunology
Acute Graft Versus Host Disease
A Study to Assess the Safety and Pharmacokinetics of GDC-8264 in Combination With Standard of Care in Participants With Acute Graft-Versus-Host Disease (aGVHD)
Neurology
Stroke
Hemophilia
Haemophilia A
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A
Skin disease
Idiopathic urticaria
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